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Enantioselective preparation of beta,beta-disubstituted alpha-methylenepropionates by MAO promotion of the zinc Schlenk equilibrium

DOI: 10.1002/anie.200463028 DOI Help
PMID: 15761887 PMID Help

Authors: Paul Goldsmith (University of Nottingham) , Simon Teat (Advanced Light Source,Berkeley, Diamond Light Source) , Simon Woodward
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Angewandte Chemie International Edition , VOL 44 (15) , PAGES 2235-2237

State: Published (Approved)
Published: March 2005

Abstract: The zinc Schlenk equilibrium, little used since it was first described in 1966, has been promoted through the addition of methylaluminoxane (MAO) to maximize the yield of ZnR2 from deleterious RZnCl by-products. This process allows an SN2?-addition approach to the preparation of chiral ?,?-disubstituted ?-methylenepropionates with high enantioselectivity (see scheme).

Journal Keywords: University Of Nottingham

Subject Areas: Chemistry


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Added On: 10/11/2010 08:51

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