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Mass spectrometry reveals potential of β-lactams as SARS-CoV-2 M pro inhibitors
Authors:
Tika R.
Malla
(University of Oxford)
,
Anthony
Tumber
(University of Oxford)
,
Tobias
John
(University of Oxford)
,
Lennart
Brewitz
(University of Oxford)
,
Claire
Strain-damerell
(Diamond Light Source; Research Complex at Harwell)
,
C. David
Owen
(Diamond Light Source; Research Complex at Harwell)
,
Petra
Lukacik
(Diamond Light Source; Research Complex at Harwell)
,
H. T. Henry
Chan
(University of Oxford)
,
Pratheesh
Maheswaran
(University of Oxford)
,
Eidarus
Salah
(University of Oxford)
,
Fernanda
Duarte
(University of Oxford)
,
Haitao
Yang
(ShanghaiTech University)
,
Zihe
Rao
(ShanghaiTech University)
,
Martin A.
Walsh
(Diamond Light Source; Research Complex at Harwell)
,
Christopher J.
Schofield
(University of Oxford)
Co-authored by industrial partner:
No
Type:
Journal Paper
Journal:
Chemical Communications
, VOL 582
State:
Published (Approved)
Published:
January 2021

Abstract: The main viral protease (Mpro) of SARS-CoV-2 is a nucleophilic cysteine hydrolase and a current target for anti-viral chemotherapy. We describe a high-throughput solid phase extraction coupled to mass spectrometry Mpro assay. The results reveal some β-lactams, including penicillin esters, are active site reacting Mpro inhibitors, thus highlighting the potential of acylating agents for Mpro inhibition.
Subject Areas:
Biology and Bio-materials
Technical Areas:
Documents:
d0cc06870e.pdf