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Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera
DOI:
10.1016/j.cell.2021.02.033
Authors:
Piyada
Supasa
(The Wellcome Centre for Human Genetics, University of Oxford)
,
Daming
Zhou
(The Wellcome Centre for Human Genetics, University of Oxford)
,
Wanwisa
Dejnirattisai
(The Wellcome Centre for Human Genetics, University of Oxford)
,
Chang
Liu
(The Wellcome Centre for Human Genetics, University of Oxford; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford)
,
Alexander J.
Mentzer
(The Wellcome Centre for Human Genetics, University of Oxford; Oxford University Hospitals NHS Foundation Trust)
,
Helen M.
Ginn
(Diamond Light Source)
,
Yuguang
Zhao
(The Wellcome Centre for Human Genetics, University of Oxford)
,
Helen M. E.
Duyvesteyn
(The Wellcome Centre for Human Genetics, University of Oxford)
,
Rungtiwa
Nutalai
(The Wellcome Centre for Human Genetics, University of Oxford)
,
Aekkachai
Tuekprakhon
(The Wellcome Centre for Human Genetics, University of Oxford)
,
Beibei
Wang
(The Wellcome Centre for Human Genetics, University of Oxford)
,
Guido
Paesen
(The Wellcome Centre for Human Genetics, University of Oxford)
,
Jose
Slon-Campos
(The Wellcome Centre for Human Genetics, University of Oxford)
,
César
López-Camacho
(The Wellcome Centre for Human Genetics, University of Oxford)
,
Bassam
Hallis
(Public Health England (PHE))
,
Naomi
Coombes
(Public Health England (PHE))
,
Kevin
Bewley
(Public Health England (PHE))
,
Sue
Charlton
(Public Health England (PHE))
,
Thomas S.
Walter
(The Wellcome Centre for Human Genetics, University of Oxford)
,
Eleanor
Barnes
(Oxford University Hospitals NHS Foundation Trust; NIHR Oxford Biomedical Research Centre)
,
Susanna J.
Dunachie
(Oxford University Hospitals NHS Foundation; University of Oxford; Mahidol-Oxford Tropical Medicine Research Unit, Bangkok)
,
Donal
Skelly
(Oxford University Hospitals NHS Foundation Trust; University of Oxford)
,
Sheila F.
Lumley
(University of Oxford)
,
Natalie
Baker
(Public Health England (PHE))
,
Imam
Shaik
(Public Health England (PHE))
,
Holly
Humphries
(Public Health England (PHE))
,
Kerry
Godwin
(Public Health England (PHE))
,
Nick
Gent
(Public Health England (PHE))
,
Alex
Sienkiewicz
(Public Health England (PHE))
,
Christina
Dold
(NIHR Oxford Biomedical Research Centre; University of Oxford)
,
Robert
Levin
(Worthing Hospital)
,
Tao
Dong
(University of Oxford)
,
Andrew J.
Pollard
(NIHR Oxford Biomedical Research Centre; University of Oxford)
,
Julian C.
Knight
(The Wellcome Centre for Human Genetics, University of Oxford; Oxford University Hospitals NHS Foundation Trust)
,
Paul
Klenerman
(Oxford University Hospitals NHS Foundation Trust; NIHR Oxford Biomedical Research Centre; University of Oxford)
,
Derrick
Crook
(University of Oxford)
,
Teresa
Lambe
(Jenner Institute, University of Oxford)
,
Elizabeth
Clutterbuck
(NIHR Oxford Biomedical Research Centre; University of Oxford)
,
Sagida
Bibi
(NIHR Oxford Biomedical Research Centre; University of Oxford)
,
Amy
Flaxman
(Jenner Institute, University of Oxford)
,
Mustapha
Bittaye
(Jenner Institute, University of Oxford)
,
Sandra
Belij-Rammerstorfer
(Jenner Institute, University of Oxford)
,
Sarah
Gilbert
(Jenner Institute, University of Oxford)
,
David R.
Hall
(Diamond Light Source)
,
Mark
Williams
(Diamond Light Source)
,
Neil G.
Paterson
(Diamond Light Source)
,
William
James
(University of Oxford)
,
Miles W.
Carroll
(The Wellcome Centre for Human Genetics, University of Oxford; Public Health England (PHE))
,
Elizabeth E.
Fry
(The Wellcome Centre for Human Genetics, University of Oxford)
,
Juthathip
Mongkolsapaya
(The Wellcome Centre for Human Genetics, University of Oxford; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford; Mahidol University)
,
Jingshan
Ren
(University of Oxford)
,
David I.
Stuart
(The Wellcome Centre for Human Genetics, University of Oxford; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford; Diamond Light Source; Instruct-ERIC)
,
Gavin R.
Screaton
(The Wellcome Centre for Human Genetics, University of Oxford; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford)
Co-authored by industrial partner:
No
Type:
Journal Paper
Journal:
Cell
State:
Published (Approved)
Published:
February 2021
Diamond Proposal Number(s):
27009

Abstract: SARS-CoV-2 has caused over 2M deaths in little over a year. Vaccines are being deployed at scale, aiming to generate responses against the virus spike. The scale of the pandemic and error-prone virus replication is leading to the appearance of mutant viruses and potentially escape from antibody responses. Variant B.1.1.7, now dominant in the UK, with increased transmission, harbours 9 amino-acid changes in the spike, including N501Y in the ACE2 interacting-surface. We examine the ability of B.1.1.7 to evade antibody responses elicited by natural SARS-CoV-2 infection or vaccination. We map the impact of N501Y by structure/function analysis of a large panel of well-characterised monoclonal antibodies. B.1.1.7 is harder to neutralize than parental virus, compromising neutralization by some members of a major class of public antibodies through light chain contacts with residue 501. However, widespread escape from monoclonal antibodies or antibody responses generated by natural infection or vaccination was not observed.
Diamond Keywords: Viruses; COVID-19
Subject Areas:
Biology and Bio-materials,
Medicine
Instruments:
I03-Macromolecular Crystallography
Added On:
23/02/2021 10:28
Discipline Tags:
Vaccines
Pathogens
Infectious Diseases
Health & Wellbeing
Biochemistry
Chemistry
Structural biology
Life Sciences & Biotech
Technical Tags: