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Does the age of pharmaceuticals matter? Undetectable hydrate seeds impact hydration behavior

DOI: 10.1021/acs.cgd.1c00100 DOI Help

Authors: Patricia A. Basford (Pfizer R&D UK Ltd) , Leigh D. Connor (Diamond Light Source) , Paul Whiteside (Pfizer R&D UK Ltd) , Aurora J. Cruz-Cabeza (University of Manchester)
Co-authored by industrial partner: Yes

Type: Journal Paper
Journal: Crystal Growth & Design

State: Published (Approved)
Published: March 2021
Diamond Proposal Number(s): 23985

Abstract: A study on the hydration behavior of fluconazole demonstrates that both sample age and polymorphic form impact the drug’s kinetic stability to hydration. For two of the polymorphs, aged samples were found to hydrate more readily than fresh samples. The aging effect was attributed to the formation of monohydrate (MH) crystals over time. The MH, despite being initially undetectable, had a seeding effect, thus impacting the hydration kinetics.

Subject Areas: Chemistry, Medicine


Instruments: I11-High Resolution Powder Diffraction

Discipline Tags:

Life Sciences & Biotech Health & Wellbeing Drug Delivery Chemistry

Technical Tags:

Diffraction X-ray Powder Diffraction