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Wide-ranging multitool study of structure and porosity of PLGA scaffolds for tissue engineering

DOI: 10.3390/polym13071021 DOI Help

Authors: Alexey V. Buzmakov (Institute of Photon Technologies of Federal Scientific Research Centre “Crystallography and Photonics” of Russian Academy of Sciences) , Andrey G. Dunaev (Institute of Photon Technologies of Federal Scientific Research Centre “Crystallography and Photonics” of Russian Academy of Sciences) , Yuriy S. Krivonosov (Institute of Photon Technologies of Federal Scientific Research Centre “Crystallography and Photonics” of Russian Academy of Sciences) , Denis A. Zolotov (Institute of Photon Technologies of Federal Scientific Research Centre “Crystallography and Photonics” of Russian Academy of Sciences) , Irina G. Dyachkova (Institute of Photon Technologies of Federal Scientific Research Centre “Crystallography and Photonics” of Russian Academy of Sciences) , Larisa I. Krotova (Institute of Photon Technologies of Federal Scientific Research Centre “Crystallography and Photonics” of Russian Academy of Sciences) , Vladimir V. Volkov (Institute of Photon Technologies of Federal Scientific Research Centre “Crystallography and Photonics” of Russian Academy of Sciences) , Andrew J. Bodey (Diamond Light Source) , Victor E. Asadchikov (Institute of Crystallography, Russian Academy of Sciences) , Vladimir K. Popov (Institute of Photon Technologies of Federal Scientific Research Centre “Crystallography and Photonics” of Russian Academy of Sciences)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Polymers , VOL 13

State: Published (Approved)
Published: March 2021
Diamond Proposal Number(s): 23866

Open Access Open Access

Abstract: In this study, the nanoscale transformation of the polylactic-co-glycolic acid (PLGA) internal structure, before and after its supercritical carbon dioxide (sc-CO2) swelling and plasticization, followed by foaming after a CO2 pressure drop, was studied by small-angle X-ray scattering (SAXS) for the first time. A comparative analysis of the internal structure data and porosity measurements for PLGA scaffolds, produced by sc-CO2 processing, on a scale ranging from 0.02 to 1000 μm, was performed by SAXS, helium pycnometry (HP), mercury intrusion porosimetry (MIP) and both “lab-source” and synchrotron X-ray microtomography (micro-CT). This approach opens up possibilities for the wide-scale evaluation, computer modeling, and prediction of the physical and mechanical properties of PLGA scaffolds, as well as their biodegradation behavior in the body. Hence, this study targets optimizing the process parameters of PLGA scaffold fabrication for specific biomedical applications.

Journal Keywords: PLGA scaffolds; supercritical fluid processing; internal structure; porosity; small-angle X-ray scattering; helium pycnometry; mercury intrusion porosimetry; X-ray microtomography

Subject Areas: Materials, Chemistry


Instruments: I13-2-Diamond Manchester Imaging

Documents:
polymers-13-01021.pdf

Discipline Tags:

Chemistry Material Sciences Polymer Science

Technical Tags:

Imaging Tomography