Making the invisible enemy visible

DOI: 10.1038/s41594-021-00593-7

Authors: Tristan I. Croll (CIMR, University of Cambridge) , Kay Diederichs (Universität Konstanz) , Florens Fischer (Universität Hamburg; Julius-Maximilians-Universität Würzburg) , Cameron D. Fyfe (Micalis Institute, INRAE) , Yunyun Gao (Universität Hamburg; Julius-Maximilians-Universität Würzburg) , Sam Horrell (Diamond Light Source) , Agnel Praveen Joseph (Science and Technology Facilities Council) , Luise Kandler (Universität Hamburg; Julius-Maximilians-Universität Würzburg) , Oliver Kippes (Universität Hamburg; Julius-Maximilians-Universität Würzburg) , Ferdinand Kirsten (Universität Hamburg; Julius-Maximilians-Universität Würzburg) , Konstantin Müller (Julius-Maximilians-Universität Würzburg) , Kristopher Nolte (Universität Hamburg; Julius-Maximilians-Universität Würzburg) , Alexander M. Payne (Memorial Sloan Kettering Cancer Center) , Matthew Reeves (Julius-Maximilians-Universität Würzburg) , Jane S. Richardson (Duke University) , Gianluca Santoni (European Synchrotron Radiation Facility) , Sabrina Stäb (Universität Hamburg; Julius-Maximilians-Universität Würzburg) , Dale E. Tronrud (Oregon State University) , Lea C. Von Soosten (Universität Hamburg; Julius-Maximilians-Universität Würzburg) , Christopher J. Williams (Duke University) , Andrea Thorn (Universität Hamburg; Julius-Maximilians-Universität Würzburg)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Nature Structural & Molecular Biology , VOL 28 , PAGES 404 - 408

State: Published (Approved)
Published: May 2021

Abstract: Structural biology plays a crucial role in the fight against COVID-19, permitting us to ‘see’ and understand SARS-CoV-2. However, the macromolecular structures of SARS-CoV-2 proteins that were solved with great speed and urgency can contain errors that may hinder drug design. The Coronavirus Structural Task Force has been working behind the scenes to evaluate and improve these structures, making the results freely available at https://insidecorona.net/.

Journal Keywords: Databases; Drug discovery; Electron microscopy; Molecular modelling; X-ray crystallography

Diamond Keywords: COVID-19; Viruses

Subject Areas: Biology and Bio-materials, Information and Communication Technology


Technical Areas:

Added On: 14/05/2021 09:43

Discipline Tags:

Vaccines Pathogens Infectious Diseases Health & Wellbeing Data management / presentation Information & Communication Technologies Structural biology Drug Discovery Life Sciences & Biotech

Technical Tags: