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3DBionotes COVID-19 edition

DOI: 10.1093/bioinformatics/btab397 DOI Help

Authors: Jose Ramon Macias (National Centre of Biotechnology (CNB-CSIC)) , Ruben Sanchez-Garcia (National Centre of Biotechnology (CNB-CSIC)) , Pablo Conesa (National Centre of Biotechnology (CNB-CSIC)) , Erney Ramirez-Aportela (National Centre of Biotechnology (CNB-CSIC)) , Marta Martinez Gonzalez (National Centre of Biotechnology (CNB-CSIC)) , Carlos Wert-Carvajal (National Centre of Biotechnology (CNB-CSIC)) , Alberto M. Parra-Perez (National Centre of Biotechnology (CNB-CSIC)) , Joan Segura Mora (University of California) , Sam Horrell (Diamond Light Source) , Andrea Thorn (Universit├Ąt Hamburg) , Carlos O. S. Sorzano (National Centre of Biotechnology (CNB-CSIC)) , Jose Maria Carazo (National Centre of Biotechnology (CNB-CSIC))
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Bioinformatics

State: Published (Approved)
Published: May 2021

Open Access Open Access

Abstract: The web platform 3DBionotes-WS integrates multiple Web Services and an interactive Web Viewer to provide a unified environment in which biological annotations can be analyzed in their structural context. Since the COVID-19 outbreak, new structural data from many viral proteins have been provided at a very fast pace. This effort includes many cryogenic Electron Microscopy (cryo-EM) studies, together with more traditional ones (X-rays, NMR), using several modeling approaches and complemented with structural predictions. At the same time, a plethora of new genomics and interactomics information (including fragment screening and structure-based virtual screening efforts) have been made available from different servers. In this context we have developed 3DBionotes-COVID-19 as an answer to: (1) The need to explore multi-omics data in a unified context with a special focus on structural information and (2) the drive to incorporate quality measurements, especially in the form of advanced validation metrics for cryogenic Electron Microscopy.

Diamond Keywords: COVID-19; Viruses

Subject Areas: Information and Communication Technology, Biology and Bio-materials

Technical Areas:

Added On: 24/05/2021 14:20


Discipline Tags:

Information & Communication Technologies Computing & software technologies Data management / presentation Life Sciences & Biotech Health & Wellbeing Infectious Diseases Pathogens

Technical Tags: