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Time-resolved in situ synchrotron-microCT: 4D deformation of bone and bone analogues using digital volume correlation
DOI:
10.1016/j.actbio.2021.06.014
Authors:
Marta
Pena Fernandez
(University of Portsmouth; Heriot-Watt University)
,
Alexander P.
Kao
(University of Portsmouth)
,
Roxane
Bonithon
(University of Portsmouth)
,
David
Howells
(Swansea University)
,
Andrew J.
Bodey
(Diamond Light Source)
,
Kazimir
Wanelik
(Diamond Light Source)
,
Frank
Witte
(Biotrics Bioimplants AG; Charité - Universitätsmedizin Berlin)
,
Richard
Johnston
(Swansea University)
,
Hari
Arora
(Swansea University)
,
Gianluca
Tozzi
(University of Portsmouth)
Co-authored by industrial partner:
No
Type:
Journal Paper
Journal:
Acta Biomaterialia
, VOL 20
State:
Published (Approved)
Published:
June 2021
Diamond Proposal Number(s):
22575
,
20132
Abstract: Digital volume correlation (DVC) in combination with high-resolution micro-computed tomography (microCT) imaging and in situ mechanical testing is gaining popularity for quantifying 3D full-field strains in bone and biomaterials. However, traditional in situ time-lapsed (i.e., interrupted) mechanical testing cannot fully capture the dynamic strain mechanisms in viscoelastic biological materials. The aim of this study was to investigate the time-resolved deformation of bone structures and analogues via continuous in situ synchrotron-radiation microCT (SR-microCT) compression and DVC to gain a better insight into their structure-function relationships. Fast SR-microCT imaging enabled the deformation behaviour to be captured with high temporal and spatial resolution. Time-resolved DVC highlighted the relationship between local strains and damage initiation and progression in the different biostructures undergoing plastic deformation, bending and/or buckling of their main microstructural elements. The results showed that SR-microCT continuous mechanical testing complemented and enhanced the information obtained from time-lapsed testing, which may underestimate the 3D strain magnitudes as a result of the stress relaxation occurring in between steps before image acquisition in porous biomaterials. Altogether, the findings of this study highlight the importance of time-resolved in situ experiments to fully characterise the time-dependent mechanical behaviour of biological tissues and biomaterials and to further explore their micromechanics under physiologically relevant conditions.
Journal Keywords: Bone; time-resolved SR-microCT; continuous in situ mechanics; digital volume correlation; time-dependent behaviour
Diamond Keywords: Bone
Subject Areas:
Biology and Bio-materials
Instruments:
I13-2-Diamond Manchester Imaging
Added On:
15/06/2021 10:34
Discipline Tags:
Biomaterials
Materials Science
Life Sciences & Biotech
Technical Tags:
Imaging
Tomography