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Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum

DOI: 10.1016/j.cell.2021.06.020 DOI Help

Authors: Chang Liu (Wellcome Centre for Human Genetics, University of Oxford; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford) , Helen M. Ginn (Diamond Light Source) , Wanwisa Dejnirattisai (Wellcome Centre for Human Genetics, University of Oxford) , Piyada Supasa (Wellcome Centre for Human Genetics, University of Oxford) , Beibei Wang (Wellcome Centre for Human Genetics, University of Oxford) , Aekkachai Tuekprakhon (Wellcome Centre for Human Genetics, University of Oxford) , Rungtiwa Nutalai (Wellcome Centre for Human Genetics, University of Oxford) , Daming Zhou (The Wellcome Centre for Human Genetics, University of Oxford) , Alexander J. Mentzer (Wellcome Centre for Human Genetics, University of Oxford; Oxford University Hospitals NHS Foundation Trust) , Yuguang Zhao (Wellcome Centre for Human Genetics, University of Oxford) , Helen M. E. Duyvesteyn (Wellcome Centre for Human Genetics, University of Oxford) , César López-Camacho (Wellcome Centre for Human Genetics, University of Oxford) , Jose Slon-Campos (Wellcome Centre for Human Genetics, University of Oxford) , Thomas Walter (Wellcome Centre for Human Genetics, University of Oxford) , Donal Skelly (Oxford University Hospitals NHS Foundation Trust; Peter Medawar Building for Pathogen Research; University of Oxford) , Sile Ann Johnson (Peter Medawar Building for Pathogen Research) , Thomas G. Ritter (Oxford University Hospitals NHS Foundation Trust) , Chris Mason (Oxford University Hospitals NHS Foundation Trust) , Sue Ann Costa Clemens (University of Siena; University of Oxford) , Felipe Gomes Naveca (Instituto Leônidas e Maria Deane) , Valdinete Nascimento (Instituto Leônidas e Maria Deane) , Fernanda Nascimento (Instituto Leônidas e Maria Deane) , Cristiano Fernandes Da Costa (Fundação de Vigilância em Saúde do Amazonas) , Paola Cristina Resende (Laboratorio de vírus respiratórios- IOC/FIOCRUZ) , Alex Pauvolid-Correa (Laboratorio de vírus respiratórios- IOC/FIOCRUZ; Texas A&M University) , Marilda M. Siqueira (Laboratorio de vírus respiratórios- IOC/FIOCRUZ) , Christina Dold (NIHR Oxford Biomedical Research Centre; University of Oxford) , Nigel Temperton (University of Kent and Greenwich) , Tao Dong (Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford; MRC Weatherall Institute of Molecular Medicine, University of Oxford) , Andrew J. Pollard (NIHR Oxford Biomedical Research Centre; University of Oxford) , Julian C. Knight (Wellcome Centre for Human Genetics, University of Oxford; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford) , Derrick Crook (University of Oxford) , Teresa Lambe (Jenner Institute, University of Oxford) , Elizabeth Clutterbuck (NIHR Oxford Biomedical Research Centre; University of Oxford) , Sagida Bibi (NIHR Oxford Biomedical Research Centre; University of Oxford) , Amy Flaxman (Jenner Institute, University of Oxford) , Mustapha Bittaye (Jenner Institute, University of Oxford) , Sandra Belij-Rammerstorfer (Jenner Institute, University of Oxford) , Sarah C. Gilbert (Jenner Institute, University of Oxford) , Tariq Malik (Public Health England (PHE)) , Miles W. Carroll (Wellcome Centre for Human Genetics, University of Oxford; Public Health England (PHE)) , Paul Klenerman (Oxford University Hospitals NHS Foundation Trust; Peter Medawar Building for Pathogen Research; NIHR Oxford Biomedical Research Centre; University of Oxford) , Eleanor Barnes (Oxford University Hospitals NHS Foundation Trust; Peter Medawar Building for Pathogen Research; NIHR Oxford Biomedical Research Centre; University of Oxford) , Susanna J. Dunachie (Oxford University Hospitals NHS Foundation Trust; Peter Medawar Building for Pathogen Research; NIHR Oxford Biomedical Research Centre; University of Oxford) , Vicky Baillie (University of the Witwatersrand, Johannesburg) , Natali Serafin (University of the Witwatersrand, Johannesburg) , Zanele Ditse (University of the Witwatersrand, Johannesburg) , Kelly Da Silva (University of the Witwatersrand, Johannesburg) , Neil G. Paterson (Diamond Light Source) , Mark A. Williams (Diamond Light Source) , David R. Hall (Diamond Light Source) , Shabir Madhi (University of the Witwatersrand, Johannesburg) , Marta C. Nunes (University of the Witwatersrand, Johannesburg) , Philip Goulder (Peter Medawar Building for Pathogen Research) , Elizabeth E. Fry (Wellcome Centre for Human Genetics, University of Oxford) , Juthathip Mongkolsapaya (Wellcome Centre for Human Genetics, University of Oxford; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford; Mahidol University) , Jingshan Ren (Wellcome Centre for Human Genetics, University of Oxford) , David I. Stuart (Wellcome Centre for Human Genetics, University of Oxford; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford; Diamond Light Source; Instruct-ERIC) , Gavin R. Screaton (Wellcome Centre for Human Genetics, University of Oxford; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Cell

State: Published (Approved)
Published: June 2021
Diamond Proposal Number(s): 27009

Abstract: SARS-CoV-2 has undergone progressive change with variants conferring advantage rapidly becoming dominant lineages e.g. B.1.617. With apparent increased transmissibility variant B.1.617.2 has contributed to the current wave of infection ravaging the Indian subcontinent and has been designated a variant of concern in the UK. Here we study the ability of monoclonal antibodies, convalescent and vaccine sera to neutralize B.1.617.1 and B.1.617.2 and complement this with structural analyses of Fab/RBD complexes and map the antigenic space of current variants. Neutralization of both viruses is reduced when compared with ancestral Wuhan related strains but there is no evidence of widespread antibody escape as seen with B.1.351. However, B.1.351 and P.1 sera showed markedly more reduction in neutralization of B.1.617.2 suggesting that individuals previously infected by these variants may be more susceptible to reinfection by B.1.617.2. This observation provides important new insight for immunisation policy with future variant vaccines in non-immune populations.

Diamond Keywords: COVID-19; Viruses

Subject Areas: Biology and Bio-materials


Instruments: I03-Macromolecular Crystallography

Added On: 22/06/2021 10:24

Discipline Tags:

Vaccines Pathogens Infectious Diseases Health & Wellbeing Structural biology Life Sciences & Biotech

Technical Tags:

Diffraction Macromolecular Crystallography (MX)