Biotransformation modulates the penetration of metallic nanomaterials across an artificial blood–brain barrier model

DOI: 10.1073/pnas.2105245118

Authors: Zhiling Guo (University of Birmingham) , Peng Zhang (University of Birmingham) , Swaroop Chakraborty (Indian Institute of Technology) , Andrew J. Chetwynd (University of Birmingham) , Fazel Abdolahpur Monikh (University of Eastern Finland) , Christopher Stark (University of Birmingham) , Hanene Ali-Boucetta (University of Birmingham) , Sandra Wilson (Sophion Bioscience A/S) , Iseult Lynch (University of Birmingham) , Eugenia Valsami-Jones (University of Birmingham)
Co-authored by industrial partner: Yes

Type: Journal Paper
Journal: Proceedings Of The National Academy Of Sciences , VOL 118

State: Published (Approved)
Published: July 2021
Diamond Proposal Number(s): 20567 , 20204

Abstract: Understanding the potential of nanomaterials (NMs) to cross the blood–brain barrier (BBB), as a function of their physicochemical properties and subsequent behavior, fate, and adverse effect beyond that point, is vital for evaluating the neurological effects arising from their unintentional entry into the brain, which is yet to be fully explored. This is not only due to the complex nature of the brain but also the existing analytical limitations for characterization and quantification of NMs in the complex brain environment. By using a fit-for-purpose analytical workflow and an in vitro BBB model, we show that the physiochemical properties of metallic NMs influence their biotransformation in biological matrices, which in turn modulates the transport form, efficiency, amounts, and pathways of NMs through the BBB and, consequently, their neurotoxicity. The data presented here will support in silico modeling and prediction of the neurotoxicity of NMs and facilitate the tailored design of safe NMs.

Journal Keywords: nanomaterials; blood–brain barrier; neurotoxicity; single-particle ICP-MS; synchrotron

Subject Areas: Biology and Bio-materials


Instruments: B18-Core EXAFS , I08-Scanning X-ray Microscopy beamline (SXM)

Added On: 18/07/2021 10:00

Documents:
e2105245118.full.pdf

Discipline Tags:

Non-Communicable Diseases Health & Wellbeing Neurology Nanoscience/Nanotechnology Life Sciences & Biotech

Technical Tags:

Microscopy Spectroscopy X-ray Microscopy Scanning X-ray Microscopy X-ray Absorption Spectroscopy (XAS)