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Pre-existing asthma as a comorbidity does not modify cytokine responses and severity of COVID-19

DOI: 10.1186/s13223-021-00569-8 DOI Help

Authors: Jian Luo (Oxford NIHR Biomedical Research Centre, University of Oxford; John Radcliffe Hospital, University of Oxford) , Yi-Ling Chen (Weatherall Institute of Molecular Medicine, University of Oxford) , Wentao Chen (Oxford NIHR Biomedical Research Centre, University of Oxford) , David A. Duncan (Weatherall Institute of Molecular Medicine, University of Oxford; Diamond Light Source) , Alexander Mentzer (Wellcome Centre for Human Genetics, University of Oxford) , Julian C. Knight (Wellcome Centre for Human Genetics, University of Oxford) , Graham Ogg (Weatherall Institute of Molecular Medicine, University of Oxford) , Paul Klenerman (University of Oxford) , Ian D. Pavord (Oxford NIHR Biomedical Research Centre, University of Oxford) , Luzheng Xue (Oxford NIHR Biomedical Research Centre, University of Oxford; John Radcliffe Hospital, University of Oxford)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Allergy, Asthma & Clinical Immunology , VOL 17

State: Published (Approved)
Published: July 2021

Open Access Open Access

Abstract: Background: A significant portion of COVID-19 sufferers have asthma. The impacts of asthma on COVID-19 progression are still unclear but a modifying effect is plausible as respiratory viruses are acknowledged to be an important trigger for asthma exacerbations and a different, potentially type-2 biased, immune response might occur. In this study, we compared the blood circulating cytokine response to COVID-19 infection in patients with and without asthma. Methods: Plasma samples and clinical information were collected from 80 patients with mild (25), severe (36) or critical (19) COVID-19 and 29 healthy subjects at the John Radcliffe Hospital, Oxford, UK. The concentrations of 51 circulating proteins in the plasma samples were measured with Luminex and compared between groups. Results: Total 16 pre-existing asthma patients were found (3 in mild, 10 in severe, and 3 in critical COVID-19). The prevalence of asthma in COVID-19 severity groups did not suggest a clear correlation between asthma and COVID-19 severity. Within the same COVID-19 severity group, no differences were observed between patients with or without asthma on oxygen saturation, CRP, neutrophil counts, and length of hospital stay. The mortality in the COVID-19 patients with asthma (12.5%) was not higher than that in patients without asthma (17.2%). No significant difference was found between asthmatic and non-asthmatic in circulating cytokine response in different COVID-19 severity groups, including the cytokines strongly implicated in COVID-19 such as CXCL10, IL-6, CCL2, and IL-8. Conclusions: Pre-existing asthma was not associated with an enhanced cytokine response after COVID-19 infection, disease severity or mortality.

Journal Keywords: Asthma; COVID-19; Cytokine storm; Mortality

Diamond Keywords: COVID-19; Asthma; Viruses

Subject Areas: Biology and Bio-materials


Technical Areas:

Added On: 18/07/2021 11:00

Documents:
Luo2021_Article_Pre-existingAsthmaAsAComorbidi.pdf

Discipline Tags:

Pathogens Infectious Diseases Health & Wellbeing Life Sciences & Biotech Allergic Diseases

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