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Order from disorder with intrinsically disordered peptide amphiphiles

DOI: 10.1021/jacs.1c06133 DOI Help

Authors: Guy Jacoby (Tel Aviv University) , Merav Segal Asher (Tel Aviv University) , Tamara Ehm (Tel Aviv University) , Inbal Abutbul Ionita (echnion-Israel Institute of Technology) , Hila Shinar (Tel Aviv University) , Salome Azoulay-Ginsburg (Tel Aviv University) , Ido Zemach (Tel Aviv University) , Gil Koren (Tel Aviv University) , Dganit Danino (Technion-Israel Institute of Technology; Guangdong-Technion Israel Institute of Technology) , Michael M. Kozlov (Tel Aviv University) , Roey J. Amir (el Aviv University) , Roy Beck (Tel Aviv University)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Journal Of The American Chemical Society , VOL 2010

State: Published (Approved)
Published: July 2021
Diamond Proposal Number(s): 24693 , 21971

Open Access Open Access

Abstract: Amphiphilic molecules and their self-assembled structures have long been the target of extensive research due to their potential applications in fields ranging from materials design to biomedical and cosmetic applications. Increasing demands for functional complexity have been met with challenges in biochemical engineering, driving researchers to innovate in the design of new amphiphiles. An emerging class of molecules, namely, peptide amphiphiles, combines key advantages and circumvents some of the disadvantages of conventional phospholipids and block copolymers. Herein, we present new peptide amphiphiles composed of an intrinsically disordered peptide conjugated to two variants of hydrophobic dendritic domains. These molecules, termed intrinsically disordered peptide amphiphiles (IDPA), exhibit a sharp pH-induced micellar phase-transition from low-dispersity spheres to extremely elongated worm-like micelles. We present an experimental characterization of the transition and propose a theoretical model to describe the pH-response. We also present the potential of the shape transition to serve as a mechanism for the design of a cargo hold-and-release application. Such amphiphilic systems demonstrate the power of tailoring the interactions between disordered peptides for various stimuli-responsive biomedical applications.

Subject Areas: Chemistry, Biology and Bio-materials

Instruments: B21-High Throughput SAXS , I22-Small angle scattering & Diffraction

Other Facilities: SIBYLS 12.3.1 at Advanced Light Source; SWING at SOLEIL

Added On: 27/07/2021 15:09


Discipline Tags:

Life Sciences & Biotech Chemistry Biochemistry

Technical Tags:

Scattering Small Angle X-ray Scattering (SAXS)