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Multi-scale structural and mechanical characterisation in bioinspired polyurethane-based pancreatic cancer model

DOI: 10.1016/j.jmrt.2021.09.041 DOI Help

Authors: Jingyi Mo (University of Surrey) , Nathanael Leung (University of Surrey) , Priyanka Gupta (University of Surrey) , Bin Zhu (University of Surrey) , Hui Xing (Shang Hai Jiao Tong University) , Jiao Zhang (Shang Hai Jiao Tong University) , Eirini Velliou (University of Surrey) , Tan Sui (University of Surrey)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Journal Of Materials Research And Technology , VOL 68

State: Published (Approved)
Published: September 2021
Diamond Proposal Number(s): 20046

Open Access Open Access

Abstract: In this work, novel bioinspired polyurethane (PU) scaffolds were fabricated via freeze casting for PU-based Pancreatic Ductal Adenocarcinoma (PDAC) model. In order to reproduce the tumour micro-environment that facilitates cellular kinetics, the PU scaffolds were surface modified with extracellular matrix (ECM) proteins including collagen and fibronectin (Col and FN). Synchrotron-based small- and wide-angle X-ray scattering (SAXS/WAXS) techniques were applied to probe structural evolution during in situ mechanical testing. Strains at macroscopic, nano-, and lattice scales were obtained to investigate the effects of ECM proteins and pancreatic cell activities to PU scaffolds. Significant mechanical strengthening across length scales of PU scaffolds was observed in specimens surface modified by FN. A model of stiffness modulation via enhanced interlamellar recruitment is proposed to explain the multi-scale strengthening mechanisms. Understanding multi-scale deformation mechanisms of a series of PU scaffolds opens an opportunity in developing a novel pancreatic cancer model for studying cancer evolution and predicting outcomes of drug/treatments.

Journal Keywords: bioinspired polyurethane; surface functionalisation; synchrotron X-ray techniques; in situ mechanical testing

Diamond Keywords: Pancreatic Cancer

Subject Areas: Biology and Bio-materials, Engineering


Instruments: B16-Test Beamline

Added On: 22/09/2021 08:50

Documents:
1-s2.0-S223878542101022X-main.pdf

Discipline Tags:

Engineering & Technology Biotechnology Life Sciences & Biotech Health & Wellbeing Cancer Non-Communicable Diseases Materials Science Biomaterials

Technical Tags:

Scattering Small Angle X-ray Scattering (SAXS) Wide Angle X-ray Scattering (WAXS)