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Novel in situ multi-level analysis of structural-mechanical relations in a bioinspired polyurethane-based tissue model
DOI:
10.1016/j.mtadv.2021.100184
Authors:
Jingyi
Mo
(University of Surrey)
,
Nathanael
Leung
(University of Surrey)
,
Priyanka
Gupta
(University of Surrey; University College London)
,
Bin
Zhu
(University of Surrey)
,
Eirini
Velliou
(University of Surrey; University College London)
,
Tan
Sui
(University of Surrey)
Co-authored by industrial partner:
No
Type:
Journal Paper
Journal:
Materials Today Advances
, VOL 12
State:
Published (Approved)
Published:
December 2021
Diamond Proposal Number(s):
20046

Abstract: In this manuscript, we elucidated, for the first time, the substructural mechanisms present in our recently developed bioinspired polyurethane-based pancreatic tissue models. Different protein coatings of the model, i.e., collagen and fibronectin were examined. More specifically, analysis took place by combined real-time synchrotron X-ray scattering techniques and confocal laser scanning microscopy, to quantify the structural alteration of uncoated-polyurethane (PU) and protein-coated PU as well as the time-resolved structural reorganisation occurring at the micro-, nano- and lattice length scales during in situ micromechanical testing. We demonstrate that a clear increase of stiffness at the lamellar level following the fibronectin-PU modification, which is linked to the changes in the mechanics of the lamellae and interlamellar cohesion. This multi-level analysis of structural-mechanical relations in this polyurethane-based pancreatic cancer tissue model opens an opportunity in designing mechanically robust cost-effective tissue models not only for fundamental research but also for treatment screening.
Journal Keywords: Bioinspired polyurethane; Surface functionalisation; Synchrotron X-ray scattering techniques; Confocal laser scanning microscopy; In situ micromechanical testing; Pancreatic cancer; Cancer cells; 3D scaffolds; Extracellular matrix (ECM); Collagen; Fibrone
Diamond Keywords: Pancreatic Cancer
Subject Areas:
Biology and Bio-materials
Instruments:
B16-Test Beamline
Added On:
08/11/2021 08:57
Documents:
1-s2.0-S2590049821000540-main.pdf
Discipline Tags:
Non-Communicable Diseases
Biomaterials
Health & Wellbeing
Cancer
Materials Science
Life Sciences & Biotech
Technical Tags:
Scattering
Small Angle X-ray Scattering (SAXS)
Wide Angle X-ray Scattering (WAXS)