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Solvent-mediated enhancement of additive-controlled crystallization

DOI: 10.1021/acs.cgd.1c01002 DOI Help

Authors: Ouassef Nahi (University of Leeds) , Alexander N. Kulak (University of Leeds) , Alexander Broad (University College London) , Yifei Xu (University of Leeds) , Cedrick O'Shaughnessy (University of Leeds) , Olivier J. Cayre (University of Leeds) , Sarah J. Day (Diamond Light Source) , Robert Darkins (University College London) , Fiona C. Meldrum (University of Leeds)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Crystal Growth & Design

State: Published (Approved)
Published: November 2021
Diamond Proposal Number(s): 27557

Abstract: Soluble additives are widely used to control crystallization processes, modifying the morphologies, sizes, polymorphs, and physical properties of the product crystals. Here, a simple and versatile strategy is shown to significantly enhance the potency of soluble additives, ranging from ions and amino acids to large dye molecules, enabling them to be effective even at low concentrations. Addition of small amounts of miscible organic co-solvents to an aqueous crystallization solution can yield enhanced morphological changes and an order of magnitude increase of additive incorporation within single crystals─a level that cannot be achieved in pure aqueous solutions at any additive concentration. The generality of this strategy is demonstrated by application to crystals of calcium carbonate, manganese carbonate, and strontium sulfate, with a more pronounced effect observed for co-solvents with lower dielectric constants and polarities, indicating a general underlying mechanism that alters water activity. This work increases the understanding of additive/crystal interactions and may see great application in industrial-scale crystal synthesis.

Journal Keywords: Additives; Crystals; Solution chemistry; Ethanol; Calcite

Subject Areas: Chemistry

Instruments: I11-High Resolution Powder Diffraction

Added On: 08/11/2021 11:40

Discipline Tags:

Chemistry Inorganic Chemistry Organic Chemistry

Technical Tags:

Diffraction X-ray Powder Diffraction