Hybrid nanoparticles as theranostics platforms for glioblastoma treatment: phototherapeutic and X-ray phase contrast tomography investigations

DOI: 10.3390/jnt3010001

Authors: Loredana Ricciardi (CNR NANOTEC) , Sharmistha Chatterjee (University of Calabria) , Giovanna Palermo (CNR NANOTEC; University of Calabria) , Elisabeta I. Szerb (Coriolan Dragulescu Institute of Chemistry, Romanian Academy) , Alessia Sanna (CNR NANOTEC) , Francesca Palermo (University of Calabria; CNR NANOTEC) , Nicola Pieroni (CNR NANOTEC) , Michela Fratini (CNR NANOTEC) , Roberto Bartolino (CNR NANOTEC) , Alessia Cedola (CNR NANOTEC) , Massimo La Deda (CNR NANOTEC; University of Calabria; National Interuniversity Consortium of Materials Science and Technology) , Giuseppe Strangi (CNR NANOTEC; University of Calabria; Case Western Reserve University)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Journal Of Nanotheranostics , VOL 3 , PAGES 1 - 17

State: Published (Approved)
Published: January 2022

Abstract: Glioblastoma multiforme (GBM) is one of the deadliest and most aggressive cancers, remarkably resilient to current therapeutic treatments. Here, we report preliminary in vivo studies of GBM treatments based on photo-nanotherapeutics to activate synergistic killing mechanisms. Core-shell nanoparticles have been weaponized by combining photophysical properties of a new generation PDT agent (Ir(III) complex) with the thermoplasmonic effects of resonant gold nanospheres. In order to investigate the damages induced in GBM treated with these photoactivable nanosystems, we employed X-ray phase-contrast tomography (XPCT). This high-resolution three-dimensional imaging technique highlighted a vast devascularization process by micro-vessels disruption, which is indicative of tumor elimination without relapse.

Journal Keywords: gold–silica nanoparticles; phototherapy; glioblastoma multiforme; X-ray phase-contrast tomography

Diamond Keywords: Brain Cancer

Subject Areas: Biology and Bio-materials, Medicine, Materials


Instruments: I13-2-Diamond Manchester Imaging

Added On: 27/01/2022 09:04

Documents:
jnt-03-00001.pdf

Discipline Tags:

Non-Communicable Diseases Health & Wellbeing Cancer Materials Science Nanoscience/Nanotechnology Drug Discovery Life Sciences & Biotech

Technical Tags:

Imaging Tomography