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Structural basis of parasitic HSP90 ATPase inhibition by small molecules

DOI: 10.3390/ph15111341 DOI Help

Authors: Giusy Tassone (University of Siena) , Marco Mazzorana (Diamond Light Source) , Cecilia Pozzi (University of Siena)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Pharmaceuticals , VOL 15

State: Published (Approved)
Published: November 2022

Open Access Open Access

Abstract: Protozoan parasites are responsible for several harmful and widespread human diseases that cause high morbidity and mortality. Currently available treatments have serious limitations due to poor efficiency, strong adverse effects, and high cost. Hence, the identification of new targets and the development of specific drug therapies against parasitic diseases are urgent needs. Heat shock protein 90 (HSP90) is an ATP-dependent molecular chaperone that plays a key role in parasite survival during the various differentiation stages, spread over the vector insect and the human host, which they undergo during their life cycle. The N-terminal domain (NTD) of HSP90, containing the main determinants for ATPase activity, represents the most druggable domain for inhibitor targeting. The molecules investigated on parasite HSP90 are mainly developed from known inhibitors of the human counterpart, and they have strong limitations due to selectivity issues, accounting for the high conservation of the ATP-binding site between the parasite and human proteins. The current review highlights the recent structural progress made to support the rational design of new molecules able to effectively block the chaperone activity of parasite HSP90.

Journal Keywords: heat shock proteins; HSP90; protozoan parasites; neglected tropical diseases; inhibitors; selectivity; chaperone function

Subject Areas: Biology and Bio-materials, Chemistry, Medicine

Technical Areas:

Added On: 03/11/2022 09:08


Discipline Tags:

Infectious Diseases Disease in the Developing World Health & Wellbeing Biochemistry Chemistry Structural biology Drug Discovery Life Sciences & Biotech Parasitology

Technical Tags: