Determining the source of elevated iron concentrations in the human pons in neurodegenerative disorders

Authors: Mary Finnegan (University of Warwick) , Joanna Collingwood (University of Warwick) , Naomi Visanji (University of Toronto, Canada) , Emily House (Keele University) , Martin Lees (University of Warwick) , Vijay Antharam (University of Florida) , Albina Mikhaylova (University of Florida) , Jon Dobson (Keele University) , Lili-naz Hazrati (University of Toronto, Canada)
Co-authored by industrial partner: No

Type: Conference Paper
Conference: The 10th International Conference on Alzheimer's & Parkinson's Diseases
Peer Reviewed: No

State: Published (Approved)
Published: March 2011
Diamond Proposal Number(s): 1125

Abstract: Disregulation of transition metal ions is implicated in many neurodegenerative disorders, and altered status may both affect disease progression and hold biomarker potential. The analytical challenges in this field often lead to isolated evidence for altered concentration, distribution, chemical or mineral state, limiting the conclusions that can be drawn. Combining methods that are highly sensitive to a range of these properties can give new insight.

Subject Areas: Medicine, Technique Development, Engineering

Instruments: I18-Microfocus Spectroscopy