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Association between nanoscale strains and tissue level nanoindentation properties in age-related hip-fractures

DOI: 10.1016/j.jmbbm.2022.105573 DOI Help

Authors: Andrea Bonicelli (University of Central Lancashire; Defence Academy of the UK) , Tabitha Tay (Imperial College London) , Justin P. Cobb (Imperial College London) , Oliver R. Boughton (Imperial College London) , Ulrich Hansen (Imperial College London) , Richard L. Abel (Imperial College London) , Peter Zioupos (Defence Academy of the UK)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Journal Of The Mechanical Behavior Of Biomedical Materials , VOL 81

State: Published (Approved)
Published: November 2022
Diamond Proposal Number(s): 17664 , 13337

Open Access Open Access

Abstract: Measurement of the properties of bone as a material can happen in various length scales in its hierarchical and composite structure. The aim of this study was to test the tissue level properties of clinically-relevant human bone samples which were collected from donors belonging to three groups: ageing donors who suffered no fractures (Control); untreated fracture patients (Fx-Untreated) and patient who experienced hip fracture despite being treated with bisphosphonates (Fx-BisTreated). Tissue level properties were assessed by (a) nanoindentation and (b) synchrotron tensile tests (STT) where strains were measured at the ‘tissue’, ‘fibril’ and ‘mineral’ levels by using simultaneous Wide-angle - (WAXD) and Small angle- X-ray diffraction (SAXD). The composition was analysed by thermogravimetric analysis and material level endo- and exo-thermic reactions by differential scanning calorimetry (TGA/DSC3+). Irrespective of treatment fracture donors exhibited significantly lower tissue, fibril and mineral strain at the micro and nanoscale respectively and had a higher mineral content than controls. In nanoindentation only nanohardness was significantly greater for Controls and Fx-BisTreated versus Fx-Untreated. The other nanoindentation parameters did not vary significantly across the three groups. There was a highly significant positive correlation (p < 0.001) between organic content and tissue level strain behaviour. Overall hip-fractures were associated with lower STT nanostrains and it was behaviour measured by STT which proved to be a more effective approach for predicting fracture risk because evidently it was able to demonstrate the mechanical deficit for the bone tissue of the donors who had experienced fractures.

Journal Keywords: Bone properties; Synchrotron; Nanoindentation; Fracture; Ageing

Diamond Keywords: Bone

Subject Areas: Biology and Bio-materials

Instruments: I22-Small angle scattering & Diffraction

Added On: 28/11/2022 09:10

Discipline Tags:

Osteoporosis Health & Wellbeing Biophysics Life Sciences & Biotech

Technical Tags:

Scattering Small Angle X-ray Scattering (SAXS) Wide Angle X-ray Scattering (WAXS)