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How vaccinia virus has evolved to subvert the host immune response

DOI: 10.1016/j.jsb.2011.03.010 DOI Help
PMID: 21419849 PMID Help

Authors: Mohammad Bahar (University of Oxford) , Stephen Graham (University of Cambridge) , Ron Chen (Imperial College London) , Samantha Cooray (Imperial College London) , Geoffrey Smith (Imperial College London) , Dave Stuart (Diamond Light Source) , Jonathan Grimes (Division of Structural Biology, University of Oxford)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Journal Of Structural Biology

State: Published (Approved)
Published: April 2011

Open Access Open Access

Abstract: Viruses are obligate intracellular parasites and are some of the most rapidly evolving and diverse pathogens encountered by the host immune system. Large complicated viruses, such as poxviruses, have evolved a plethora of proteins to disrupt host immune signalling, in their battle against immune surveillance. Recent X-ray crystallographic analysis of these viral immunomodulators has helped form an emerging picture of the molecular details of virus-host interactions. In this review we consider some of these immune evasion strategies as they apply to poxviruses, from a structural perspective, with specific examples from the European SPINE2-Complexes initiative. Structures of poxvirus immunomodulators reveal the capacity of viruses to mimic and compete against the host immune system, using a diverse range of structural folds that are unique or acquired from their hosts with both enhanced and unexpectedly divergent functions.

Journal Keywords: Structural virology; Innate immunity; Cell signalling; X-ray crystallography; Surface receptors

Subject Areas: Biology and Bio-materials


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