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Alanine response to low energy synchrotron x-ray radiation

DOI: 10.1088/1361-6560/acb886 DOI Help

Authors: Peregrin Van Den Elzen (National Physical Laboratory (UK)) , Thorsten Sander (National Physical Laboratory (UK)) , Hugo Palmans (National Physical Laboratory (UK)) , Michael Mcmanus (National Physical Laboratory (UK)) , Nathaniel Woodall (National Physical Laboratory (UK)) , Nigel Lee (National Physical Laboratory (UK)) , Oliver J. L. Fox (Diamond Light Source) , Roger Michael Jones (The University of Manchester) , Deepa Angal-Kalinin (Cockcroft Institute) , Anna Subiel (National Physical Laboratory (UK))
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Physics In Medicine & Biology

State: Published (Approved)
Published: February 2023

Open Access Open Access

Abstract: Alanine pellets with a nominal thickness of 0.5 mm and diameter of 5 mm were irradiated with monoenergetic x-rays at the Diamond Light Source synchrotron, to quantify their response in the 8 to 20 keV range relative to 60Co radiation. The absorbed dose to graphite was measured with a small portable graphite calorimeter, and the DOSRZnrc code in the EGSnrc Monte Carlo package was used to calculate conversion factors between the measured dose to graphite and the absorbed dose to water delivered to the alanine pellets. GafChromic EBT3 films were used to measure the beam profile for modelling in the MC simulations. The relative responses measured in this energy range were found to range from 0.616 to 0.643, with a combined relative expanded uncertainty of 3.4% to 3.5% (k = 2), where the majority of the uncertainty originated from the uncertainty in the alanine readout, due to the small size of the pellets used. The measured values were in good agreement with previously published data in the overlapping region of x-ray energies, while this work extended the dataset to lower energies. By measuring the response to monoenergetic x-rays, the response to a more complex broad-spectrum x-ray source can be inferred if the spectrum is known, meaning that this work supports the establishment of alanine as a secondary standard dosimeter for low-energy x-ray sources.

Subject Areas: Biology and Bio-materials, Medicine

Instruments: B16-Test Beamline

Added On: 07/02/2023 10:10


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Physics Biophysics Life Sciences & Biotech

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