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Microcalcification crystallography as a potential marker of DCIS recurrence

DOI: 10.1038/s41598-023-33547-8 DOI Help

Authors: Sarah B. Gosling (Keele University) , Emily L. Arnold (Cranfield University) , Samantha K. Davies (Cranfield University) , Hannah Cross (Keele University) , Ihssane Bouybayoune (King's College London) , Doriana Calabrese (University of Exeter) , Jayakrupakar Nallala (University of Exeter) , Sarah E. Pinder (King's College London) , Liping Fu (The Netherlands Cancer Institute) , Esther H. Lips (The Netherlands Cancer Institute) , Lorraine King (Duke University Medical Center) , Jeffrey Marks (Duke University Medical Center) , Allison Hall (University of British Colombia) , Lars J. Grimm (Duke University) , Thomas Lynch (Duke University Medical Center) , Donna Pinto ( , Hilary Stobart (Independent Cancer Patients' Voice) , E. Shelley Hwang (Duke University Medical Center) , Jelle Wesseling (The Netherlands Cancer Institute; Leiden University Medical Center) , Kalotina Geraki (Diamond Light Source) , Nicholas Stone (University of Exeter) , Iain D. Lyburn (Cranfield University; Gloucestershire Hospitals NHS Foundation Trust; Cobalt Medical Charity) , Charlene Greenwood (Keele University) , Keith D. Rogers (Cranfield University) , Alastair Thompson (Grand Challenge PRECISION Consortium) , Serena Nik-Zainal (Grand Challenge PRECISION Consortium) , Elinor J. Sawyer (Grand Challenge PRECISION Consortium) , Helen Davies (Grand Challenge PRECISION Consortium) , Andrew Futreal (Grand Challenge PRECISION Consortium) , Nicholas Navin (Grand Challenge PRECISION Consortium) , Jos Jonkers (Grand Challenge PRECISION Consortium) , Jacco Van Rheenen (Grand Challenge PRECISION Consortium) , Fariba Behbod (Grand Challenge PRECISION Consortium) , Marjanka Schmidt (Grand Challenge PRECISION Consortium) , Lodewyk F. A. Wessels (Grand Challenge PRECISION Consortium) , Daniel Rea (Grand Challenge PRECISION Consortium) , Proteeti Bhattacharjee (Grand Challenge PRECISION Consortium) , Deborah Collyar (Grand Challenge PRECISION Consortium) , Ellen Verschuur (Grand Challenge PRECISION Consortium) , Marja Van Oirsouw (Grand Challenge PRECISION Consortium)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Scientific Reports , VOL 13

State: Published (Approved)
Published: June 2023
Diamond Proposal Number(s): 21565 , 25414 , 27300 , 23072

Open Access Open Access

Abstract: Ductal carcinoma in-situ (DCIS) accounts for 20–25% of all new breast cancer diagnoses. DCIS has an uncertain risk of progression to invasive breast cancer and a lack of predictive biomarkers may result in relatively high levels (~ 75%) of overtreatment. To identify unique prognostic biomarkers of invasive progression, crystallographic and chemical features of DCIS microcalcifications have been explored. Samples from patients with at least 5-years of follow up and no known recurrence (174 calcifications in 67 patients) or ipsilateral invasive breast cancer recurrence (179 microcalcifications in 57 patients) were studied. Significant differences were noted between the two groups including whitlockite relative mass, hydroxyapatite and whitlockite crystal maturity and, elementally, sodium to calcium ion ratio. A preliminary predictive model for DCIS to invasive cancer progression was developed from these parameters with an AUC of 0.797. These results provide insights into the differing DCIS tissue microenvironments, and how these impact microcalcification formation.

Diamond Keywords: Breast Cancer

Subject Areas: Biology and Bio-materials, Medicine

Instruments: I18-Microfocus Spectroscopy

Added On: 12/06/2023 10:18


Discipline Tags:

Non-Communicable Diseases Health & Wellbeing Cancer Life Sciences & Biotech

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