Protein target highlights in CASP15 : Analysis of models by structure providers

DOI: 10.1002/prot.26545

Authors: Leila T. Alexander (University of Basel; SIB Swiss Institute of Bioinformatics) , Janani Durairaj (University of Basel; SIB Swiss Institute of Bioinformatics) , Andriy Kryshtafovych (University of California, Davis,) , Luciano A. Abriata (École Polytechnique Fédérale de Lausanne) , Yusupha Bayo (University of Milano; IBBA-CNR Unit of Milano) , Gira Bhabha (University School of Medicine) , Cécile Breyton (Univ. Grenoble Alpes, CNRS, CEA, IBS) , Simon G. Caulton (The University of Birmingham) , James Chen (New York University School of Medicine) , Séraphine Degroux (Univ. Grenoble Alpes, CNRS, CEA, IBS) , Damian C. Ekiert (New York University School of Medicine) , Benedikte S. Erlandsen (University of Edinburgh) , Peter L. Freddolino (University of Michigan) , Dominic Gilzer (Bielefeld University) , Chris Greening (Monash University) , Jonathan M. Grimes (Wellcome Centre for Human Genetics, University of Oxford) , Rhys Grinter (Monash University; Monash Institute of Pharmaceutical Sciences) , Manickam Gurusaran (University of Edinburgh) , Marcus D. Hartmann (Max Planck Institute for Biology; University of Tübingen) , Charlie J. Hitchman (University of Leicester) , Jeremy R. Keown (University of Oxford) , Ashleigh Kropp (Monash University) , Petri Kursula (University of Bergen; University of Oulu) , Andrew L. Lovering (The University of Birmingham) , Bruno Lemaitre (École Polytechnique Fédérale de Lausanne) , Andrea Lia (University of Leicester; ISPA-CNR Unit of Lecce) , Shiheng Liu (University of California, Los Angeles) , Maria Logotheti (Max Planck Institute for Biology; University of Tübingen) , Shuze Lu (Lanzhou University) , Sigurbjorn Markusson (University of Bergen) , Mitchell D. Miller (Rice University) , George Minasov (Northwestern Feinberg School of Medicine) , Hartmut H. Niemann (Bielefeld University) , Felipe Opazo (NanoTag Biotechnologies GmbH; University of Göttingen Medical Center) , George N. Phillips (Rice University) , Owen R. Davies (University of Edinburgh) , Samuel Rommelaere (École Polytechnique Fédérale de Lausanne) , Monica Rosas‐lemus (Northwestern Feinberg School of Medicine) , Pietro Roversi (IBBA-CNR Unit of Milano; University of Leicester) , Karla Satchell (Northwestern Feinberg School of Medicine) , Nathan Smith (University of Nebraska) , Mark A. Wilson (University of Nebraska) , Kuan‐lin Wu (Rice University) , Xian Xia (University of California, Los Angeles) , Han Xiao (Rice University) , Wenhua Zhang (Lanzhou University) , Z. Hong Zhou (University of California, Los Angeles) , Krzysztof Fidelis (University of California, Davis) , Maya Topf (University Medical Center Hamburg-Eppendorf (UKE); Leibniz-Institut für Virologie (LIV)) , John Moult (University of Maryland) , Torsten Schwede (University of Basel; SIB Swiss Institute of Bioinformatics)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Proteins: Structure, Function, And Bioinformatics , VOL 78

State: Published (Approved)
Published: July 2023
Diamond Proposal Number(s): 19946 , 23570 , 27314 , 28534

Abstract: We present an in-depth analysis of selected CASP15 targets, focusing on their biological and functional significance. The authors of the structures identify and discuss key protein features and evaluate how effectively these aspects were captured in the submitted predictions. While the overall ability to predict three-dimensional protein structures continues to impress, reproducing uncommon features not previously observed in experimental structures is still a challenge. Furthermore, instances with conformational flexibility and large multimeric complexes highlight the need for novel scoring strategies to better emphasize biologically relevant structural regions. Looking ahead, closer integration of computational and experimental techniques will play a key role in determining the next challenges to be unraveled in the field of structural molecular biology.

Diamond Keywords: CASP; cryo-EM; protein structure prediction; X-ray crystallography

Subject Areas: Biology and Bio-materials


Instruments: VMXm-Versatile Macromolecular Crystallography microfocus

Added On: 28/07/2023 08:19

Discipline Tags:

Structural biology Life Sciences & Biotech

Technical Tags:

Diffraction Macromolecular Crystallography (MX)