Directed Formation of DNA Nanoarrays through Orthogonal Self-Assembly

DOI: 10.3390/molecules16064912
PMID: 21677604

Authors: Jon Burns (University of Southampton) , Jurgita Zekonyte , Guiliano Siligardi (Diamond Light Source) , Rohanah Hussain (Diamond Light Source) , Eugen Stulz (University of Southampton)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Molecules , VOL 16 (6) , PAGES 4912 - 4922

State: Published (Approved)
Published: June 2011

Abstract: We describe the synthesis of terpyridine modified DNA strands which selectively form DNA nanotubes through orthogonal hydrogen bonding and metal complexation interactions. The short DNA strands are designed to self-assemble into long duplexes through a sticky-end approach. Addition of weakly binding metals such as Zn(II) and Ni(II) induces the formation of tubular arrays consisting of DNA bundles which are 50-200 nm wide and 2-50 nm high. TEM shows additional long distance ordering of the terpy-DNA complexes into fibers.

Subject Areas: Biology and Bio-materials


Instruments: B23-Circular Dichroism

Added On: 04/07/2011 11:34

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