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xtalPiMS: A PiMS-based web application for the management and monitoring of crystallization trials

DOI: 10.1016/j.jsb.2011.05.008 DOI Help
PMID: 21605683 PMID Help

Authors: Ed Daniel (STFC Daresbury Laboratory) , Bill Lin (STFC Daresbury Laboratory) , Jonathan Diprose (University of Oxford) , Susanne Griffiths (University of York) , Chris Morris (Science and Technology Facilities Council (STFC)) , Ian M Berry (University of Oxford) , Raymond J. Owens (University of Oxford) , Richard Blake (University of Oxford) , Keith Wilson (University of York) , Dave Stuart (Diamond Light Source) , Robert Esnouf (University of Oxford)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Journal Of Structural Biology , VOL 175 (2) , PAGES 230-235

State: Published (Approved)
Published: August 2011

Open Access Open Access

Abstract: A major advance in protein structure determination has been the advent of nanolitre-scale crystallization and (in a high-throughput environment) the development of robotic systems for storing and imaging crystallization trials. Most of these trials are carried out in 96-well (or higher density) plates and managing them is a significant information management challenge. We describe xtalPiMS, a web-based application for the management and monitoring of crystallization trials. xtalPiMS has a user-interface layer based on the standards of the Protein Information Management System (PiMS) and a database layer which links the crystallization trial images to the meta-data associated with a particular crystallization trial. The user interface has been optimized for the efficient monitoring of high-throughput environments with three different automated imagers and work to support a fourth imager is in progress, but it can even be of use without robotics. The database can either be a PiMS database or a legacy database for which a suitable mapping layer has been developed.

Journal Keywords: Laboratory Information Management Systems (LIMS); Protein crystallization; Robotic imagers; Java web application; Data management and databases

Subject Areas: Biology and Bio-materials


Technical Areas: