Convenient Solution-Phase Synthesis and Conformational Studies of Novel Linear and Cyclic α,β-Alternating Peptoids

DOI: 10.1021/ol9015767

Authors: Thomas Hjelmgaard (Clermont Université, Université Blaise Pascal) , Sophie Faure (Clermont Université, Université Blaise Pascal) , Cécile Caumes (Clermont Université, Université Blaise Pascal) , Emiliana De Santis (Medway School of Pharmacy) , Alison Edwards (Medway School of Pharmacy) , Claude Taillefumier (Clermont Université, Université Blaise Pascal)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Organic Letters , VOL 11 (18) , PAGES 4100 - 4103

State: Published (Approved)
Published: August 2009

Abstract: The synthesis of a novel family of peptidomimetics composed of linear and cyclic α,β-alternating peptoids is described. Oligomers consisting of up to six peptoid residues (n = 1−3) were synthesized on large scale with use of an efficient iterative solution-phase method and longer oligomers (n = 4, 5) were obtained by the coupling of appropriately protected shorter oligomers. Preliminary conformational studies of these hybrid peptoids are reported.

Subject Areas: Chemistry


Instruments: B23-Circular Dichroism