Structure of the topoisomerase IV from S. pneumoniae with a DNA target and quinolone drug

Authors: Ivan Laponogov (King's College London) , Maninder Sohi (King's College London) , Dennis Veselkov (King's College London) , Xiao-su Pan , Ritica Sawhney , Andrew Thompson , Mark Fisher , Mark Sanderson (King's College London)
Co-authored by industrial partner: No

Type: Poster

State: Published (Approved)
Published: January 2008
Diamond Proposal Number(s): 1220

Abstract: Eighteen percent of all clinical bacterial infections are now treated with quinolone based antibiotics [1], which target the decatenating enzyme topoisomerase IV (a Class II topo) in gram-positive bacteria such as S. pneumoniae.

Journal Keywords: Topoisomerase Dna Quinolone

Subject Areas: Medicine, Biology and Bio-materials

Instruments: I02-Macromolecular Crystallography , I03-Macromolecular Crystallography , I04-Macromolecular Crystallography