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Microfocus study of metal distribution and speciation in tissue extracted from revised metal on metal hip implants

DOI: 10.1088/1742-6596/190/1/012208 DOI Help

Authors: Ann Sandison (Charring Cross Hospital) , Barry Sampson (Imperial College and Imperial College Healthcare NHS Trust) , Kirk Atkinson (Nuclear Department Defence Academy College of Management & Technology) , John Skinner (Royal National Orthopaedic Hospital) , Angela Goode (Imperial College London) , Jonathan Powell (Medical Research Council Human Nutrition Research Centre) , Fred Mosselmans (Diamond Light Source) , Paul Quinn (Diamond Light Source) , Alister Hart (Imperial College and Imperial College Healthcare NHS Trust)
Co-authored by industrial partner: No

Type: Conference Paper
Peer Reviewed: No

State: Published (Approved)
Published: July 2009

Abstract: Unexplained tissue inflammation in metal-on-metal hip replacements is suspected to be caused by implant-derived nanoparticles. The aim of this study was to investigate the nature of the metal particles in tissue surrounding metal-on-metal (MOM) hips that has been extracted during revision. Mapping of tissue surrounding the failed MOM hips was performed using microfocus X-ray Fluorescence (XRF). This revealed mainly Cr which was localized to the cellular regions. There was co-localisation of Co, were present, to areas of high Cr abundance. XANES of the tissue and appropriate standards revealed that the most common species were Cr(III) and Co(II). EXAFS analysis of the tissue and various metal standards revealed that the most abundant implant-related species was Cr(III) phosphate. Different tissue preparation methods, including frozen sectioning, were examined but were found not to affect the distribution or speciation of the metals in the tissue.

Subject Areas: Medicine

Instruments: I18-Microfocus Spectroscopy