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The structure of a Burkholderia pseudomallei immunophilin–inhibitor complex reveals new approaches to antimicrobial development

DOI: 10.1042/BJ20110345 DOI Help
PMID: 21574961 PMID Help

Authors: Isobel H. Norville (University of Exeter; U.K.Defence Science and Technology Laboratory) , Katherine O'shea (University of Exeter; U.K.Defence Science and Technology Laboratory) , Mitali Sarkar‑tyson (Defence Science and Technology Laboratory) , Suxin Zheng (University of Washington) , Richard W. Titball (University of Exeter) , Gabriele Varani (University of Washington) , Nicholas J. Harmer (University of Exeter)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Biochemical Journal , VOL 437 (3) , PAGES 413 - 422

State: Published (Approved)
Published: May 2011

Abstract: Prolyl-peptide isomerase, Burkholderia pseudomallei, X-ray crystallography, NMR, small molecule inhibitor.

Journal Keywords: Bacterial; Burkholderia; Gene; Bacterial; Immunophilins; Models; Molecular; Protein; Tacrolimus; Virulence

Subject Areas: Biology and Bio-materials


Instruments: I03-Macromolecular Crystallography

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