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Henry reaction catalyzed by copper(I) complexes of a new pyridine-containing macrocyclic ligand

DOI: 10.1002/aoc.1846 DOI Help

Authors: Brunilde Castano (Università degli Studi) , Tommaso Pedrazzini (Università degli Studi) , Massimo Sisti (Università degli Studi dell'Insubria) , Emma Gallo (Università degli Studi) , Fabio Ragaini (Università degli Studi) , Nicola Casati (Diamond Light Source) , Alessandro Caselli (Università degli Studi)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Applied Organometallic Chemistry

State: Published (Approved)
Published: October 2011

Abstract: The synthesis and characterization of copper(I) complexes of the novel pyridine-containing macrocyclic ligand (PC-L) and their use as catalysts in the Henry reaction are reported. The pyridine-based 12-membered tetraaza macrocyclic (PC-L) ligand 1 can be obtained in good overall yield (85%) from commercially available starting materials. The Cu(I) complexes showed good catalytic activities in the Henry reaction of different aldehydes and nitroalkanes. Remarkable diastereoselectivity was observed when isatine was reacted with nitroethane under catalytic conditions. Copyright (C) 2011 John Wiley & Sons, Ltd.

Journal Keywords: Henry Reaction; Homogeneous Catalysis; Pyridine-Containing Macrocyclic Ligands; Copper(I) Complexes; Isatines

Subject Areas: Chemistry

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