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Sequence Divergent RXLR Effectors Share a Structural Fold Conserved across Plant Pathogenic Oomycete Species

DOI: 10.1371/journal.ppat.1002400 DOI Help
PMID: 22253591 PMID Help

Authors: Joe Win (Norwich Research Park, Norwich, U.K.) , Ksenia V. Krasileva (Department of Plant and Microbial Biology, University of California, USA.) , Sophien Kamoun (Norwich Research Park, Norwich, U.K.) , Ken Shirasu , Brian J. Staskawicz (Department of Plant and Microbial Biology, University of California, USA.) , Mark J. Banfield (John Innes Centre, U.K.)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: PLoS Pathogens , VOL 8 (1)

State: Published (Approved)
Published: January 2012
Diamond Proposal Number(s): 7641

Open Access Open Access

Abstract: The availability of genome sequences for some of the most devastating eukaryotic plant pathogens has led a revolution in our understanding of how these parasites cause disease, and how their hosts respond to invasion. One of the most significant discoveries from the genome sequences of plant pathogenic oomycetes is the plethora of putative translocated effector proteins these organisms encode. Many effector genes display signatures of rapid evolution and tend to reside in dynamic regions of the pathogen genomes. Once inside the host, effector proteins modulate cellular processes, mainly suppressing plant immunity. Effectors can also be recognized directly or indirectly by the plant immune system through the action of disease resistance proteins

Subject Areas: Biology and Bio-materials


Instruments: I02-Macromolecular Crystallography , I04-Macromolecular Crystallography