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An exploration of the polymorphism of piracetam using high pressure

DOI: 10.1039/b418976k DOI Help

Authors: Francesca P.a. Fabbiani (School of Chemistry and Centre for Science at Extreme Conditions, The University of Edingburgh, West Mains Road, Edingburgh) , Dave Allan (Diamond Light Source) , Simon Parsons (School of Chemistry and Centre for Science at Extreme Conditions, The University of Edingburgh, West Mains Road, Edingburgh) , Colin Pulham (University of Edinburgh)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Crystengcomm , VOL 7 , PAGES 179-186

State: Published (Approved)
Published: March 2005

Abstract: High-pressure recrystallisation of aqueous and methanolic solutions of piracetam (2-oxo-pyrrolidineacetamide) contained in a diamond-anvil cell at pressures of 0.07–0.4 GPa resulted in the formation of a new high-pressure polymorph of piracetam that has been characterised by in situ X-ray diffraction. The molecular packing arrangement of the new form is very different from those of forms I, II, and III, and the piracetam molecules also adopt a very different conformation in this new phase. Depressurisation to ambient pressure resulted in the formation of form II via a single-crystal to single-crystal transition. By contrast, crystallisation of piracetam from water at ambient pressure resulted in the formation of a new monohydrate of piracetam, which has been characterised by single crystal X-ray diffraction.

Subject Areas: Medicine, Chemistry


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Added On: 01/04/2012 13:26

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