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High-pressure recrystallisation - a route to new polymorphs and solvates
Authors:
F. P. A.
Fabbiani
(School of Chemistry, The University of Edinburgh, U.K.)
,
Dave
Allan
(Diamond Light Source)
,
W. I. F
David
(ISIS Pulsed Neutron and Muon Facility, Rutherford Appleton Laboratory, U.K.)
,
S
Moggach
(The University of Edinburgh)
,
S
Parsons
(The University of Edinburgh)
,
Colin
Pulham
(University of Edinburgh)
Co-authored by industrial partner:
No
Type:
Journal Paper
Journal:
Crystengcomm
, VOL 6
, PAGES 504-511
State:
Published (Approved)
Published:
September 2004
Abstract: The recrystallisation of organic compounds from solution under high-pressure conditions is shown to be a versatile method for the formation of new polymorphs and solvates. The technique is illustrated by the crystallisation of a new polymorph of phenanthrene from dichloromethane at a pressure of 0.7 GPa, and the crystallisation of a novel dihydrate of paracetamol from water at a pressure of 1.1 GPa. These phases have been characterised by single crystal X-ray diffraction. We also demonstrate that the technique can be used to prepare a polymorph that is metastable under ambient conditions. Thus the orthorhombic form of paracetamol was crystallised from ethanol at a pressure of 1.1 GPa.
Subject Areas:
Chemistry
Facility: Daresbury Laboratory, U.K.
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