High-pressure recrystallisation - a route to new polymorphs and solvates

DOI: 10.1039/b406631f

Authors: F. P. A. Fabbiani (School of Chemistry, The University of Edinburgh, U.K.) , Dave Allan (Diamond Light Source) , W. I. F David (ISIS Pulsed Neutron and Muon Facility, Rutherford Appleton Laboratory, U.K.) , S Moggach (The University of Edinburgh) , S Parsons (The University of Edinburgh) , Colin Pulham (University of Edinburgh)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Crystengcomm , VOL 6 , PAGES 504-511

State: Published (Approved)
Published: September 2004

Abstract: The recrystallisation of organic compounds from solution under high-pressure conditions is shown to be a versatile method for the formation of new polymorphs and solvates. The technique is illustrated by the crystallisation of a new polymorph of phenanthrene from dichloromethane at a pressure of 0.7 GPa, and the crystallisation of a novel dihydrate of paracetamol from water at a pressure of 1.1 GPa. These phases have been characterised by single crystal X-ray diffraction. We also demonstrate that the technique can be used to prepare a polymorph that is metastable under ambient conditions. Thus the orthorhombic form of paracetamol was crystallised from ethanol at a pressure of 1.1 GPa.

Subject Areas: Chemistry

Facility: Daresbury Laboratory, U.K.

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