Publication

Mapping Collagen Orientation Changes In The Corneas Of Blindness Enlarged Globe (beg) Chicken Mutants

Authors: Sian Morgan (School of Optometry and Vision Sciences, Cardiff University) , Erin Dooley (School of Optometry and Vision Sciences, Cardiff University) , Paul Hocking (Roslin Institute, University of Edinburgh) , Chris Inglehearn (University of Leeds) , Manir Ali (University of Leeds) , Thomas Sorensen (Diamond Light Source) , Keith Meek (School of Optometry and Vision Sciences, Cardiff University) , Craig Boote (School of Optometry and Vision Sciences, Cardiff University)
Co-authored by industrial partner: No

Type: Conference Paper
Conference: ARVO 2012: Annual Meeting of the Association for Research in Vision and Ophthalmology
Peer Reviewed: No

State: Published (Approved)
Published: May 2012
Diamond Proposal Number(s): 6098

Abstract: The precise relationship between corneal shape and the organization of stress-bearing collagen in the stroma remains to be clarified. The aim of the current study was to define potential changes in collagen organisation in the blindness enlarged globe (beg) phenotype, an inherited autosomal recessive condition in chickens. The beg phenotype is characterised by retinal dystrophy and blindness at hatch, with secondary globe-enlargement and loss of corneal curvature by age 3-4 months.

Journal Keywords: Cornea; Collagen; X-Ray Scattering

Subject Areas: Biology and Bio-materials, Physics


Instruments: I02-Macromolecular Crystallography

Added On: 26/07/2012 15:10

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