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Co-Crystalization and In Vitro Biological Characterization of 5-Aryl-4-(5-Substituted-2-4-Dihydroxyphenyl)-1,2,3-Thiadiazole Hsp90 Inhibitors

DOI: 10.1371/journal.pone.0044642 DOI Help
PMID: 22984537 PMID Help

Authors: Swee Y. Sharp , S. Mark Roe , Egidijus Kazlauskas , Inga Čikotienė , Paul Workman , Daumantas Matulis , Chrisostomos Prodromou
Co-authored by industrial partner: No

Type: Journal Paper
Journal: PLoS ONE , VOL 7 (9) , PAGES e44642

State: Published (Approved)
Published: September 2012
Diamond Proposal Number(s): 6385

Open Access Open Access

Abstract: targeting cancer, ATPase activity of the molecular chaperone Hsp90, 5-aryl-4-(5-substituted-2-4-dihydroxyphe​nyl)-1,2,3-thiadiazoles, depletion of Hsp90 clients, CRAF, ERBB2 and CDK4, clinical trial candidate NVP-AUY922, human Hsp90α N-terminal domain, Thiadiazole

Journal Keywords: Apoptosis ; Cell; Tumor ; Crystallization ; Crystallography ; X-Ray ; Drug; Antitumor ; HSP27; HSP72; HSP90; Humans ; In; Inhibitory; Models ; Chemical ; Mutation ; Protein; Tertiary ; Recombinant; Thiadiazoles ; Tumor; Biological

Subject Areas: Biology and Bio-materials, Medicine, Chemistry


Instruments: I02-Macromolecular Crystallography

Added On: 26/09/2012 16:34

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