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Structure, Function, and Evolution of the Crimean-Congo Hemorrhagic Fever Virus Nucleocapsid Protein

DOI: 10.1128/JVI.01555-12 DOI Help
PMID: 22875964 PMID Help

Authors: Stephen Carter (University of Leeds) , Rebecca Surtees (University of Leeds) , Cheryl T Walter (University of Leeds, U.K.) , Antonio Ariza (University of Leeds) , Eric Bergeron (Centers for Disease Control and Prevention, Atlanta, USA) , Stuart T Nichol (Centers for Disease Control and Prevention, Atlanta, USA) , Julian A Hiscox (University of Leeds, U.K.) , Thomas A Edwards (University of Leeds, U.K.) , John N Barr (University of Leeds, U.K.)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Journal Of Virology , VOL 86 (20) , PAGES 10914-10923

State: Published (Approved)
Published: October 2012
Diamond Proposal Number(s): 6386

Abstract: Crimean-Congo hemorrhagic fever virus (CCHFV) is an emerging tick-borne virus of the Bunyaviridae family responsible for fatal human disease for which preventative or therapeutic measures do not exist. We solved the crystal structure of the Baghdad-12 strain CCHFV nucleocapsid protein (N), a potential therapeutic target, at a resolution of 2.1 angstroms.

Journal Keywords: Caspase; Crystallography ; X-Ray ; Evolution ; Molecular ; Hemorrhagic; Crimean-Congo ; Hemorrhagic; Crimean ; Nucleocapsid ; Nucleocapsid; Phylogeny ; Protein; Tertiary ; RNA ; Viral ; RNA-Binding; Sequence Alignment

Subject Areas: Biology and Bio-materials

Instruments: I02-Macromolecular Crystallography , I03-Macromolecular Crystallography , I04-1-Macromolecular Crystallography (fixed wavelength) , I04-Macromolecular Crystallography , I24-Microfocus Macromolecular Crystallography

Added On: 01/10/2012 21:33

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