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Metal–organic frameworks for the storage and delivery of biologically active hydrogen sulfide

DOI: 10.1039/c2dt12069k DOI Help

Authors: Phoebe K. Allan (University of St Andrews, U.K.) , Paul S. Wheatley (University of St Andrews, U.K.) , David Aldous (University of St Andrews, U.K.) , M. Infas Mohideen (University of St Andrews, U.K.) , Chiu Tang (Diamond Light Source) , Joseph A. Hriljac (University of Birmingham, U.K.) , Ian L. Megson (Free Radical Research Facility, UHI Millennium Institute, U.K.) , Karena W. Chapman (Advanced Photon Source, USA.) , Guy De Weireld (Université de Mons, Belgium) , Sebastian Vaesen (Université de Mons, Belgium) , Russell E. Morris (University of St Andrews, U.K.)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Dalton Transactions , VOL 41 (14) , PAGES 4060-4066

State: Published (Approved)
Published: March 2012

Abstract: Hydrogen sulfide is an extremely toxic gas that is also of great interest for biological applications when delivered in the correct amount and at the desired rate. Here we show that the highly porous metal-organic frameworks with the CPO-27 structure can bind the hydrogen sulfide relatively strongly, allowing the storage of the gas for at least several months. Delivered gas is biologically active in preliminary vasodilation studies of porcine arteries, and the structure of the hydrogen sulfide molecules inside the framework has been elucidated using a combination of powder X-ray diffraction and pair distribution function analysis.

Subject Areas: Chemistry


Instruments: I11-High Resolution Powder Diffraction

Other Facilities: Advanced Photon Source