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Small-Angle X-ray Scattering Investigations of Biomolecular Confinement, Loading, and Release from Liquid-Crystalline Nanochannel Assemblies

DOI: 10.1021/jz2014727 DOI Help

Authors: Angelina Angelova (CNRS UMR8612 Physico-chimie-Pharmacotechnie-Biopharmacie, France) , Borislav Angelov (Academy of Sciences of the Czech Republic, Czech Republic) , Vasil M. Garamus (Helmholtz-Zentrum Geesthacht, Centre for Materials and Coastal Research, Germany) , Patrick Couvreur (CNRS UMR8612 Physico-chimie-Pharmacotechnie-Biopharmacie, France) , Sylviane Lesieur (CNRS UMR8612 Physico-chimie-Pharmacotechnie-Biopharmacie, France)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: The Journal Of Physical Chemistry Letters , VOL 3 (3) , PAGES 445-457

State: Published (Approved)
Published: January 2012
Diamond Proposal Number(s): 3313

Abstract: This Perspective explores the recent progress made by means of small-angle scattering methods in structural studies of phase transitions in amphiphilic liquid-crystalline systems with nanochannel architectures and outlines some future directions in the area of hierarchically organized and stimuli-responsive nanochanneled assemblies involving biomolecules. Time-resolved small-angle X-ray scattering investigations using synchrotron radiation enable monitoring of the structural dynamics, the modulation of the nanochannel hydration, as well as the key changes in the soft matter liquid-crystalline organization upon stimuli-induced phase transitions. They permit establishing of the inner nanostructure transformation kinetics and determination of the precise sizes of the hydrophobic membraneous compartments and the aqueous channel diameters in self-assembled network architectures. Time-resolved structural studies accelerate novel biomedical, pharmaceutical, and nanotechnology applications of nanochannel soft materials by providing better control of DNA, peptide and protein nanoconfinement, and release from diverse stimuli-responsive nanocarrier systems.

Subject Areas: Chemistry

Instruments: I22-Small angle scattering & Diffraction

Added On: 15/11/2012 13:26

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