Peptide length determines the outcome of T cell receptor/peptide-MHCI engagement

DOI: 10.1182/blood-2012-06-437202
PMID: 23255554

Authors: J. Ekeruche-makinde (Cardiff University, U.K.) , John Miles (Cardiff University) , H. A. Van Den Berg , A. Skowera , D. K. Cole (Cardiff University, U.K.) , G. Dolton (Cardiff University, U.K.) , A. J. A. Schauenburg (Cardiff University, U.K.) , M. P. Tan (Cardiff University, U.K.) , J. M. Pentier (Cardiff University, U.K.) , S. Llewellyn-lacey (Cardiff University, U.K.) , K. M. Miles (Cardiff University, U.K.) , A. M. Bulek (Cardiff University, U.K.) , M. Clement (Cardiff University, U.K.) , T. Williams (Cardiff University, U.K.) , A. Trimby (Cardiff University, U.K.) , M. Bailey (University of Bristol, U.K.) , Pierre Rizkallah (Cardiff University) , J. Rossjohn (Cardiff University, U.K.) , M. Peakman (King's College London, U.K.) , D. A. Price (Cardiff University, U.K.)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Blood , VOL 121 (7) , PAGES 1112-1123

State: Published (Approved)
Published: December 2012

Abstract: MHCI-restricted TCRs exhibit an explicit preference for a single MHCI-peptide length. Effective CD8+ T-cell immunity can only be achieved by length-matched Ag-specific T-cell clonotypes.

Journal Keywords: Antigen; Antigens ; CD8-Positive; Clone; Histocompatibility; Humans ; Immunity ; Cellular ; Models ; Molecular ; Oligopeptides ; Peptide; Peptide; Receptors ; Antigen ; T-Cell ; alpha-beta

Subject Areas: Biology and Bio-materials


Instruments: I03-Macromolecular Crystallography

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