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Nitric Oxide Adsorption and Delivery in Flexible MIL-88(Fe) Metal-Organic Frameworks

DOI: 10.1021/cm304037x DOI Help

Authors: A. C. Mckinlay (University of St Andrews) , J. F. Eubank (Institut Lavoisier, UMR CNRS 8180, Université de Versailles Saint-Quentin-en-Yvelines) , S. Wuttke (Institut Lavoisier, UMR CNRS 8180, Université de Versailles Saint-Quentin-en-Yvelines) , B. Xiao (University of St Andrews) , P. S. Wheatley (University of St Andrews) , P. Bazin (Université de Caen) , J.-c. Lavalley (Université de Caen) , M. Daturi (Université de Caen) , A. Vimont (Université de Caen) , G. De Weireld (Université de Mons) , P. Horcajada (Université de Versailles Saint-Quentin-en-Yvelines) , C. Serre (Université de Versailles Saint-Quentin-en-Yvelines) , R. E. Morris (University of St Andrews)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Chemistry Of Materials

State: Published (Approved)
Published: March 2013

Abstract: Adsorption and release of the biologically active nitric oxide (NO) was evaluated over a series of highly flexible iron(III) dicarboxylate MOFs of the MIL-88 structure type, bearing fumaric or terephthalic spacer functionalized or not by polar groups (NO2, 2OH). As evidenced by ex situ X-ray powder diffraction and in situ IR spectroscopy, it appears that if the contracted dried forms of MIL-88 do not expand their structures in the presence of NO, the combination of very narrow pores and trimers of iron polyhedra leads to the adsorption of significant amounts of NO either physisorbed (very narrow pores) and/or chemisorbed [iron(II) or iron(III) coordinatively unsaturated metal sites (CUS)]. The delivery of NO under vapor of water or in simulated body fluid does not exceed 20% range of the total adsorbed amount probably due to a partial release that occurs between the adsorption/desorption setup and the chemiluminescence release tests. Some of these solids nevertheless exhibit a significant release at the biological levels over a long period of time (>16 h) that make these biocompatible and biodegradable MOFs of interest for the controlled release of NO.

Journal Keywords: Nitric Oxide; Metal Organic Frameworks; Iron Carboxylates; Flexibility; Infrared Spectroscopy

Subject Areas: Materials


Instruments: I11-High Resolution Powder Diffraction

Added On: 04/04/2013 09:09

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