A unique spumavirus Gag N-terminal domain with functional properties of orthoretroviral matrix and capsid

DOI: 10.1371/journal.ppat.1003376
PMID: 23675305

Authors: David C. Goldstone (MRC National Institute for Medical Research) , Thomas G. Flower (MRC National Institute for Medical Research) , Neil J. Ball (MRC National Institute for Medical Research) , Marta Sanz-Ramos (MRC National Institute for Medical Research) , Melvyn W. Yap (MRC National Institute for Medical Research) , Roksana Ogrodowicz (MRC National Institute for Medical Research) , Nicole Stanke (Technische Universität Dresden) , Juliane Reh (Technische Universität Dresden) , Dirk Lindemann (Technische Universität Dresden) , Jonathan P. Stoye (MRC National Institute for Medical Research) , Ian A. Taylor (MRC National Institute for Medical Research)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Plos Pathogens , VOL 9 (5)

State: Published (Approved)
Published: May 2013

Abstract: The Spumaretrovirinae, or foamyviruses (FVs) are complex retroviruses that infect many species of monkey and ape. Although FV infection is apparently benign, trans-species zoonosis is commonplace and has resulted in the isolation of the Prototypic Foamy Virus (PFV) from human sources and the potential for germ-line transmission.

Journal Keywords: Biological; Capsid; Cell; Gene; gag; Humans; Protein; Quaternary; Protein; Tertiary; Simian; Transfection

Diamond Keywords: Viruses

Subject Areas: Biology and Bio-materials


Instruments: I03-Macromolecular Crystallography

Added On: 24/05/2013 15:25

Documents:
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Discipline Tags:

Pathogens Infectious Diseases Health & Wellbeing Structural biology Life Sciences & Biotech

Technical Tags:

Diffraction Macromolecular Crystallography (MX)