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A Unique Spumavirus Gag N-terminal Domain with Functional Properties of Orthoretroviral Matrix and Capsid

DOI: 10.1371/journal.ppat.1003376 DOI Help
PMID: 23675305 PMID Help

Authors: David Goldstone (MRC, National Institute for Medical Research) , Thomas G. Flower , Neil J. Ball , Marta Sanz-Ramos , Melvyn Yap (MRC, National Institute for Medical Research) , Roksana Ogrodowicz (MRC, National Institute for Medical Research) , Nicole Stanke , Juliane Reh , Dirk Lindemann , Jonathan P. Stoye , Ian A. Taylor , Christopher Aiken
Co-authored by industrial partner: No

Type: Journal Paper
Journal: PLoS Pathogens , VOL 9 (5)

State: Published (Approved)
Published: May 2013

Open Access Open Access

Abstract: The Spumaretrovirinae, or foamyviruses (FVs) are complex retroviruses that infect many species of monkey and ape. Although FV infection is apparently benign, trans-species zoonosis is commonplace and has resulted in the isolation of the Prototypic Foamy Virus (PFV) from human sources and the potential for germ-line transmission.

Journal Keywords: Biological; Capsid ; Cell; Gene; gag ; Humans ; Protein; Quaternary ; Protein; Tertiary ; Simian; Transfection

Subject Areas: Biology and Bio-materials


Instruments: I03-Macromolecular Crystallography

Added On: 24/05/2013 15:25

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