Structural basis and selectivity of tankyrase inhibition by a Wnt signaling inhibitor WIKI4

DOI: 10.1371/journal.pone.0065404
PMID: 23762361

Authors: Teemu Haikarainen (University of Oulu) , Harikanth Venkannagari (University of Oulu) , Mohit Narwal (University of Oulu; Abo Akademi University) , Ezeogo Obaji (University of Oulu) , Hao-Wei Lee (University of Oulu) , Yves Nkizinkiko (Abo Akademi University) , Lari Lehtiö (University of Oulu)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Plos One , VOL 8 (6)

State: Published (Approved)
Published: January 2013

Abstract: Recently a novel inhibitor of Wnt signaling was discovered. The compound, WIKI4, was found to act through tankyrase inhibition and regulate â-catenin levels in many cancer cell lines and human embryonic stem cells.

Journal Keywords: Antineoplastic; Catalytic; Cell; Tumor; Crystallography; X-Ray; Enzyme; Humans;NAD; Naphthalimides; Protein; Recombinant; Sensitivity; Tankyrases; Triazoles; Wnt Signaling Pathway

Diamond Keywords: Enzymes

Subject Areas: Biology and Bio-materials, Medicine


Instruments: I04-1-Macromolecular Crystallography (fixed wavelength)

Added On: 12/06/2013 14:46

Documents:
file.pdf

Discipline Tags:

Non-Communicable Diseases Health & Wellbeing Cancer Structural biology Drug Discovery Life Sciences & Biotech

Technical Tags:

Diffraction Macromolecular Crystallography (MX)