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Structural basis and selectivity of tankyrase inhibition by a Wnt signaling inhibitor WIKI4
DOI:
10.1371/journal.pone.0065404
PMID:
23762361
Authors:
Teemu
Haikarainen
(University of Oulu)
,
Harikanth
Venkannagari
(University of Oulu)
,
Mohit
Narwal
(University of Oulu; Abo Akademi University)
,
Ezeogo
Obaji
(University of Oulu)
,
Hao-Wei
Lee
(University of Oulu)
,
Yves
Nkizinkiko
(Abo Akademi University)
,
Lari
Lehtiö
(University of Oulu)
Co-authored by industrial partner:
No
Type:
Journal Paper
Journal:
Plos One
, VOL 8 (6)
State:
Published (Approved)
Published:
January 2013

Abstract: Recently a novel inhibitor of Wnt signaling was discovered. The compound, WIKI4, was found to act through tankyrase inhibition and regulate â-catenin levels in many cancer cell lines and human embryonic stem cells.
Journal Keywords: Antineoplastic; Catalytic; Cell; Tumor; Crystallography; X-Ray; Enzyme; Humans;NAD; Naphthalimides; Protein; Recombinant; Sensitivity; Tankyrases; Triazoles; Wnt Signaling Pathway
Diamond Keywords: Enzymes
Subject Areas:
Biology and Bio-materials,
Medicine
Instruments:
I04-1-Macromolecular Crystallography (fixed wavelength)
Added On:
12/06/2013 14:46
Documents:
file.pdf
Discipline Tags:
Non-Communicable Diseases
Health & Wellbeing
Cancer
Structural biology
Drug Discovery
Life Sciences & Biotech
Technical Tags:
Diffraction
Macromolecular Crystallography (MX)