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Synthesis of Oxindole-Based Bioorganometallic Kinase Inhibitors Incorporating One or More Ferrocene Groups

DOI: 10.1021/om400359m DOI Help

Authors: Jahangir Amin (University of Sussex) , Irina S. Chuckowree (University of Sussex) , Minghua Wang (University of Toronto) , Graham Tizzard (University of Southampton) , Simon Coles (University of Southampton) , John Spencer (University of Sussex)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Organometallics , VOL 32 (20)

State: Published (Approved)
Published: June 2013

Abstract: A series of oxindole-containing ferrocenes has been synthesized, studied in the solid state by X-ray crystallography, and tested for in vitro kinase inhibition. Many compounds show low or submicromolar activities against DYRK isoforms and VEGFR2, which in certain cases have been rationalized by molecular docking studies.

Subject Areas: Chemistry, Biology and Bio-materials

Instruments: I19-Small Molecule Single Crystal Diffraction

Added On: 01/07/2013 14:06

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