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Femtolitre chemistry assisted by microfluidic pen lithography
DOI:
10.1038/ncomms3173
PMID:
23863998
Authors:
Carlos
Carbonell
(ICN2—Institut Catala de Nanociencia i Nanotecnologia)
,
Kyriakos C.
Stylianou
(ICN2—Institut Catala de Nanociencia i Nanotecnologia)
,
Jordi
Hernando
(Universitat Autònoma de Barcelona)
,
Emi
Evangelio
(ICN2—Institut Catala de Nanociencia i Nanotecnologia)
,
Sarah
Barnett
(Diamond Light Source)
,
Saju
Nettikadan
(NanoInk Inc.)
,
Inhar
Imaz
(Catalan Institute of Nanotechnology)
,
Daniel
Maspoch
(Catalan Institute of Nanotechnology)
Co-authored by industrial partner:
No
Type:
Journal Paper
Journal:
Nature Communications
, VOL 4
State:
Published (Approved)
Published:
July 2013

Abstract: Chemical reactions at ultrasmall volumes are becoming increasingly necessary to study biological processes, to synthesize homogenous nanostructures and to perform high-throughput assays and combinatorial screening. Here we show that a femtolitre reaction can be realized on a surface by handling and mixing femtolitre volumes of reagents using a microfluidic stylus. This method, named microfluidic pen lithography, allows mixing reagents in isolated femtolitre droplets that can be used as reactors to conduct independent reactions and crystallization processes. This strategy overcomes the high-throughput limitations of vesicles and micelles and obviates the usually costly step of fabricating microdevices and wells. We anticipate that this process enables performing distinct reactions (acid-base, enzymatic recognition and metal-organic framework synthesis), creating multiplexed nanoscale metal-organic framework arrays, and screening combinatorial reactions to evaluate the crystallization of novel peptide-based materials.
Journal Keywords: Materials science; Microfluidics; Techniques and instrumentation
Subject Areas:
Technique Development,
Chemistry
Technical Areas:
Added On:
07/08/2013 10:34
Documents:
ncomms3173.pdf
Discipline Tags:
Technique Development - Chemistry
Chemistry
Technical Tags: