Crystal structure of signal regulatory protein gamma (SIRPã) in complex with an antibody Fab fragment

DOI: 10.1186/1472-6807-13-13
PMID: 23826770

Authors: Joanne E. Nettleship , Jingshan Ren , David J Scott , Nahid Rahman , Debbie Hatherley (University of Oxford) , Yuguang Zhao , Dave Stuart (Diamond Light Source) , A Barclay , Raymond Owens (University of Oxford)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: BMC Structural Biology , VOL 13

State: Published (Approved)
Published: July 2013

Abstract: Signal Regulatory Protein ? (SIRP?) is a member of a closely related family of three cell surface receptors implicated in modulating immune/inflammatory responses. SIRP? is expressed on T lymphocytes where it appears to be involved in the integrin-independent adhesion of lymphocytes to antigen-presenting cells. Here we describe the first full length structure of the extracellular region of human SIRP?.

Journal Keywords: Antigen-Binding Complex; Signal Regulatory Protein; Receptor Structure

Subject Areas: Biology and Bio-materials


Instruments: I03-Macromolecular Crystallography

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