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Structure of an 'open' clamp type II topoisomerase-DNA complex provides a mechanism for DNA capture and transport

DOI: 10.1093/nar/gkt749 DOI Help
PMID: 23965305 PMID Help

Authors: Ivan Laponogov (King's College London) , Dennis Veselkov (King's College London) , Isabelle M.- T. Crevel (St. George’s, University of London) , Xiao-su Pan (University of London) , L. Mark Fisher (St. George’s, University of London) , Mark Sanderson (Kings College London)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Nucleic Acids Research

State: Published (Approved)
Published: August 2013

Open Access Open Access

Abstract: Type II topoisomerases regulate DNA supercoiling and chromosome segregation. They act as ATP-operated clamps that capture a DNA duplex and pass it through a transient DNA break in a second DNA segment via the sequential opening and closure of ATPase-, G-DNA- and C-gates

Journal Keywords: Adenosine; Binding; Biological; DNA; DNA; Models; Molecular; Protein; Tertiary; Streptococcus pneumoniae

Subject Areas: Biology and Bio-materials

Instruments: I03-Macromolecular Crystallography , I04-1-Macromolecular Crystallography (fixed wavelength) , I24-Microfocus Macromolecular Crystallography