Publication

Article Metrics

Citations


Online attention

Structure of the Repulsive Guidance Molecule (RGM)-Neogenin Signaling Hub

DOI: 10.1126/science.1232322 DOI Help
PMID: 23744777 PMID Help

Authors: Christian H. Bell (Wellcome Trust Centre for Human Genetics, University of Oxford) , Eleanor Healey (Wellcome Trust Centre for Human Genetics, University of Oxford) , Susan Van Erp (University Medical Center Utrecht) , Benjamin Bishop (Wellcome Trust Centre for Human Genetics, University of Oxford) , Chenxiang Tang (Wellcome Trust Centre for Human Genetics, University of Oxford) , Robert J. C. Gilbert (Wellcome Trust Centre for Human Genetics, University of Oxford) , Alexandru Aricescu (Wellcome Trust Centre for Human Genetics, University of Oxford) , R. Jeroen Pasterkamp (University Medical Center Utrecht) , Christian Siebold (Wellcome Trust Centre for Human Genetics, University of Oxford)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Science , VOL 341 (6141) , PAGES 77 - 80

State: Published (Approved)
Published: July 2013
Diamond Proposal Number(s): 8423

Abstract: Repulsive guidance molecule family members (RGMs) control fundamental and diverse cellular processes, including motility and adhesion, immune cell regulation, and systemic iron metabolism. However, it is not known how RGMs initiate signaling through their common cell-surface receptor, neogenin (NEO1). Here, we present crystal structures of the NEO1 RGM-binding region and its complex with human RGMB (also called dragon).

Journal Keywords: Biophysical; Cell; Neuronal; Conserved; Crystallography; X-Ray; Humans; Membrane; Mutation; Oligopeptides; Protein; Tertiary; Signal Transduction

Subject Areas: Biology and Bio-materials, Medicine


Instruments: I03-Macromolecular Crystallography

Other Facilities: ESRF

Discipline Tags:



Technical Tags: