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Recognition of sulphated and fucosylated receptor sialosides by A/Vietnam/1194/2004 (H5N1) influenza virus

DOI: 10.1016/j.virusres.2013.08.007 DOI Help
PMID: 24036174 PMID Help

Authors: X. Xiong (National Institute for Medical Research) , A. Tuzikov (United Institute of Informatics Problems, National Academy of Sciences of Belarus) , P. J. Coombs (National Institute for Medical Research) , S. R, Martin (National Institute for Medical Research) , P. A. Walker (National Institute for Medical Research) , S. J. Gamblin (National Institute for Medical Research) , N. Bovin (Shemyakin Institute of Bioorganic Chemistry) , J. J. Skehel (National Institute for Medical Research)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Virus Research

State: Published (Approved)
Published: September 2013
Diamond Proposal Number(s): 7707

Abstract: •We report the structures of 4 sialoside receptor analogues complexed with H5 HA. The analogues included fucosylated and/or sulphated GlcNAc at position 3. Estimates of affinity of HA for the analogues were made by biolayer interferometry.

Journal Keywords: Influenza; Humans; Influenza; H5N1; Influenza; Human; Models; Molecular; Protein; Receptors; Virus

Diamond Keywords: Influenza; Viruses

Subject Areas: Biology and Bio-materials


Instruments: I04-1-Macromolecular Crystallography (fixed wavelength)

Added On: 30/09/2013 16:49

Discipline Tags:

Pathogens Infectious Diseases Health & Wellbeing Structural biology Life Sciences & Biotech

Technical Tags:

Diffraction Macromolecular Crystallography (MX)