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Mid-infrared (IR) A hot topic: The potential for using mid-IR light for non-invasive early detection of skin cancer in vivo
Authors:
Angela
Seddon
(University of Nottingham)
Co-authored by industrial partner:
No
Type:
Journal Paper
Journal:
Physica Status Solidi (b)
, VOL 250 (5)
, PAGES 1020–-1027
State:
Published (Approved)
Published:
May 2013
Diamond Proposal Number(s):
7294
,
8230
,
8712
Abstract: After an introduction to the mid-infrared (IR) spectral region, the tremendous significance of mid-IR spectroscopic sensing is highlighted. The remarkable progress made towards mid-IR spectral in vitro mapping of tissue and cancer detection is reviewed, with emphasis on diagnosis of skin cancer. The status quo of chalcogenide glass mid-IR fibre optics and photonics for meeting opportunities for remote mid-IR sensing in general, and in in vivo cancer detection in particular, is assessed. Raman spectroscopy is a sister technique to mid-IR spectroscopy. The current success of Raman spectroscopy in medical diagnosis is appraised, with particular emphasis on Raman spectral imaging of tissue towards skin cancer diagnosis in vivo, based on a silica-glass fibreoptic sensor-head. The challenges to be met in chalcogenide glass science and technology towards facilitating analogous fibreoptic diagnostics based on mid-IR spectroscopy are addressed.
Journal Keywords: Skin Cancer; Mid-Infrared Spectroscopy; Fibreoptics
Subject Areas:
Medicine,
Physics,
Technique Development
Instruments:
B22-Multimode InfraRed imaging And Microspectroscopy