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Structural insights into proteoglycan-shaped Hedgehog signaling

DOI: 10.1073/pnas.1310097110 DOI Help
PMID: 24062467 PMID Help

Authors: Daniel Whalen (University of Oxford) , Tomas Malinauskas (University of Oxford) , Robert J. C. Gilbert (University of Oxford) , Christian Siebold (Wellcome Trust Centre for Human Genetics, University of Oxford)
Co-authored by industrial partner: No

Type: Journal Paper
Journal: Proceedings Of The National Academy Of Sciences

State: Published (Approved)
Published: September 2013

Abstract: Hedgehog (Hh) morphogens play fundamental roles during embryogenesis and adulthood, in health and disease. Multiple cell surface receptors regulate the Hh signaling pathway. Among these, the glycosaminoglycan (GAG) chains of proteoglycans shape Hh gradients and signal transduction. We have determined crystal structures of Sonic Hh complexes with two GAGs, heparinand chondroitin sulfate.

Journal Keywords: Affinity; Escherichia; Glycosaminoglycans; Hedgehog; Humans; Models; Molecular; Mutagenesis; Site-Directed; Polymerization; Protein; Proteoglycans; Signal; Ultracentrifugation

Subject Areas: Biology and Bio-materials

Instruments: I03-Macromolecular Crystallography